{"id":"W2007468850","doi":"10.1021/jm040134d","title":"Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Chemistry; Subgenomic mRNA; Replicon; Hepatitis C virus; RNA polymerase; Nucleoside; Allosteric regulation; RNA-dependent RNA polymerase; Polymerase; Virology; Benzimidazole; Viral replication; Virus; RNA; Enzyme; Biochemistry; Hepacivirus; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691309,0.0003009381,0.0003526051,0.0001457513,0.0001158937,0.0001625207,0.0002570388,0.0001553647,0.0007318175],"category_scores_gemma":[0.0001520413,0.0001025773,0.0001544941,0.0001763674,0.000135833,0.0001241123,0.0001300783,0.0003259895,0.0002654711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002800924,"about_ca_system_score_gemma":0.0002224628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126384,"about_ca_topic_score_gemma":0.005498159,"domain_scores_codex":[0.9998963,0.00002058681,0.000009078853,0.00001224114,0.00003649612,0.00002533353],"domain_scores_gemma":[0.9999459,0.00001362011,0.00001183394,0.000005894429,0.00001073902,0.00001210347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002184404,0.0001010173,0.000165937,0.00007051373,0.000006371663,0.00004935913,0.00002289569,0.0004204476,0.993968,0.000110837,0.00008441827,0.004781668],"study_design_scores_gemma":[0.0001113861,0.001244628,0.001433454,0.000006013538,0.00002173528,0.0001705011,0.0000108351,0.001131241,0.9935251,0.00002934858,0.002308198,0.000007602912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860013,0.005285856,0.004906626,0.0001184796,0.00004746263,0.0001525534,0.0003664011,0.000115815,0.003005469],"genre_scores_gemma":[0.9866335,0.004207815,0.006070501,0.00005613545,0.00002076285,0.00007731503,0.0007189756,0.00002344327,0.002191466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126384,"threshold_uncertainty_score":0.002448201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157469874561512,"score_gpt":0.2636050793259859,"score_spread":0.2520303805803707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}