{"id":"W2007468850","doi":"10.1021/jm040134d","title":"Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Chemistry; Subgenomic mRNA; Replicon; Hepatitis C virus; RNA polymerase; Nucleoside; Allosteric regulation; RNA-dependent RNA polymerase; Polymerase; Virology; Benzimidazole; Viral replication; Virus; RNA; Enzyme; Biochemistry; Hepacivirus; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009713628,0.0003306651,0.001034495,0.0003327731,0.00008555457,0.0000181899,0.000381091,0.0003058102,0.0002142946],"category_scores_gemma":[0.0004956183,0.0002716097,0.0004341145,0.0007305342,0.0006496344,0.0001214853,0.0001150203,0.001213024,0.00000811109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007775946,"about_ca_system_score_gemma":0.002029494,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01170154,"about_ca_topic_score_gemma":0.001560117,"domain_scores_codex":[0.9954128,0.0001009502,0.001979294,0.0003235249,0.001686586,0.0004968024],"domain_scores_gemma":[0.9969003,0.0001808578,0.001370734,0.000629547,0.0005004001,0.0004181405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005670836,0.0005242981,0.07612794,0.0006937883,0.00009032813,0.00066477,0.0004155488,0.0002201249,0.9181882,0.000001574752,0.0004206311,0.002085695],"study_design_scores_gemma":[0.005187149,0.0005969056,0.05244865,0.003459503,0.0001568507,0.0002599602,0.00008790087,0.00009652664,0.9373056,0.00003981422,0.0001724114,0.0001887688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962677,0.0009016141,0.00004626213,0.001576191,0.0002607487,0.0003705511,0.0001005677,0.00001747744,0.0004588309],"genre_scores_gemma":[0.9974235,0.001240149,0.0003178106,0.0004328977,0.0004471986,0.00001067916,0.00001235131,0.00008320427,0.00003218351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02367929,"threshold_uncertainty_score":0.9999736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157469874561512,"score_gpt":0.2636050793259859,"score_spread":0.2520303805803707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}