{"id":"W2007472764","doi":"10.1038/mt.2014.24","title":"SNS01-T Modulation of eIF5A Inhibits B-cell Cancer Progression and Synergizes With Bortezomib and Lenalidomide","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Cancer research; Bortezomib; Biology; Lenalidomide; Programmed cell death; Cell growth; Apoptosis; Immunology; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008406412,0.000113307,0.0001230928,0.00002719589,0.00004360099,0.00001284852,0.00005405769,0.00006264088,0.000002219358],"category_scores_gemma":[0.000005552015,0.00008600784,0.00002204546,0.00005575051,0.00008756337,0.000003970181,0.00002982549,0.00003408945,2.661296e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001643102,"about_ca_system_score_gemma":0.00001767597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000243972,"about_ca_topic_score_gemma":0.000006758963,"domain_scores_codex":[0.9994206,0.00004248115,0.0001123196,0.0002299506,0.00008490687,0.0001096874],"domain_scores_gemma":[0.9996195,0.000004950567,0.00008346199,0.0001947288,0.00004737533,0.00005002735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008643261,0.00003746676,0.001434256,0.0000125359,0.00002019172,2.40027e-7,0.00002608226,0.00004802931,0.9601731,0.0002319673,0.0000202796,0.03790941],"study_design_scores_gemma":[0.001325549,0.0001725807,0.006994285,0.00001791047,0.00001442501,0.000003435237,0.000006723958,0.0002865006,0.9816555,0.0001360814,0.00926487,0.0001221186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854847,0.007188615,0.006755449,0.0001533966,0.0000120641,0.0001985871,0.000008247448,0.000006801793,0.0001922002],"genre_scores_gemma":[0.9964077,0.001877959,0.00129911,0.0001762266,0.00004408632,0.00005718146,0.00003319961,0.00001875662,0.00008578562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03778729,"threshold_uncertainty_score":0.3507298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004098630609009743,"score_gpt":0.2411156325398769,"score_spread":0.2370170019308672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}