{"id":"W2007480962","doi":"10.1007/s10637-013-9974-3","title":"Preclinical analysis of resistance and cross-resistance to low-dose metronomic chemotherapy","year":2013,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research; University of Texas at El Paso; Canada Research Chairs; University Health Network","keywords":"Docetaxel; Cyclophosphamide; Medicine; Chemotherapy; Pharmacology; Oncology; Drug resistance; Bevacizumab; Nitrogen mustard; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008218114,0.0005728978,0.0009192085,0.0007201974,0.0002656299,0.0004596909,0.0006027194,0.0005085446,0.002940121],"category_scores_gemma":[0.0006996745,0.0003009608,0.0005102713,0.0004363373,0.000451524,0.0005927571,0.0002268212,0.001908786,0.0005186818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006753503,"about_ca_system_score_gemma":0.0003792584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009997003,"about_ca_topic_score_gemma":0.0009429744,"domain_scores_codex":[0.9993355,0.0001960425,0.00005285074,0.00008757025,0.0001134355,0.0002145947],"domain_scores_gemma":[0.9993948,0.0001735084,0.0001256184,0.00009743908,0.00007505147,0.0001336282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00891532,0.01151954,0.002232748,0.0001662296,0.0001095079,0.0001653166,0.0001586475,0.001878484,0.9560029,0.0007900483,0.001124324,0.01693691],"study_design_scores_gemma":[0.001109548,0.1139335,0.01413054,0.00002173096,0.0002240969,0.0008467046,0.0001377322,0.006234635,0.858459,0.0002612202,0.004606158,0.00003517582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959707,0.0009163597,0.0009464512,0.000132945,0.0000523423,0.000179895,0.0004477928,0.00008580767,0.001267701],"genre_scores_gemma":[0.9959509,0.0005177097,0.0007097655,0.00004749505,0.00002859227,0.0001591869,0.0006176923,0.00003207696,0.001936422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002940121,"threshold_uncertainty_score":0.00983566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427079223169009,"score_gpt":0.2999322824445219,"score_spread":0.2856614902128318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}