{"id":"W2007493729","doi":"10.1016/s1521-6616(03)00177-3","title":"No detrimental effect from chronic exposure to buprenorphine on corticosteroid-binding globulin and corticosensitive immune parameters","year":2003,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"","keywords":"Buprenorphine; Corticosterone; Internal medicine; Endocrinology; Immune system; Glucocorticoid; Globulin; Corticosteroid; Glucocorticoid receptor; Stimulation; Transcortin; Splenocyte; Chemistry; Medicine; Immunology; Opioid; Spleen; Hormone; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542362,0.0004929545,0.0007987611,0.0002476996,0.0002430931,0.0004604834,0.0003058576,0.0006777291,0.005187896],"category_scores_gemma":[0.0008921373,0.0002625227,0.000407998,0.0002327891,0.001097946,0.0005824824,0.0002849735,0.001327433,0.0005870786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384801,"about_ca_system_score_gemma":0.0004993941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006698769,"about_ca_topic_score_gemma":0.001230699,"domain_scores_codex":[0.9996519,0.00007918951,0.00001839168,0.00006021084,0.00008289412,0.0001073384],"domain_scores_gemma":[0.9985153,0.0005292194,0.0001499844,0.0003415425,0.0001276742,0.000336189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06777318,0.001497515,0.005217863,0.0002324949,0.000201039,0.0006543992,0.0001787817,0.0001582843,0.9009158,0.0002383495,0.0004476581,0.0224847],"study_design_scores_gemma":[0.0009501423,0.05516522,0.1309977,0.00007880687,0.0005028038,0.002136991,0.0005502263,0.0007272478,0.8022751,0.0005379482,0.006021282,0.00005648856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954454,0.001985346,0.0004764981,0.0001577017,0.0001721793,0.0000356394,0.0003558144,0.00003191054,0.001339563],"genre_scores_gemma":[0.9943998,0.0006382751,0.0003706974,0.0001329008,0.00008578174,0.00004571358,0.0004124652,0.00001678722,0.003897439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005187896,"threshold_uncertainty_score":0.01735526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422191708051664,"score_gpt":0.3209739895630115,"score_spread":0.2967520724824949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}