{"id":"W2007517393","doi":"10.1158/1535-7163.mct-09-0148","title":"Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Hsp27; Bladder cancer; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer research; Cytotoxicity; In vivo; Medicine; Heat shock protein; Cancer; Pharmacology; Apoptosis; Chemistry; Internal medicine; Biology; In vitro; Hsp70; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001249331,0.0003549786,0.0002881599,0.00006776187,0.0001704096,0.0001002881,0.0001553318,0.0002126323,0.00001563495],"category_scores_gemma":[0.00001015297,0.0002944322,0.00007861041,0.0001474372,0.0001355317,0.00001379189,0.00003661541,0.0001468248,0.000001225759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360598,"about_ca_system_score_gemma":0.0003774845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005100211,"about_ca_topic_score_gemma":0.0001527049,"domain_scores_codex":[0.9981986,0.00007941628,0.0002531777,0.0006122034,0.0002900357,0.0005665686],"domain_scores_gemma":[0.999227,0.00001310707,0.0000614031,0.0003191014,0.0002150749,0.0001643006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004465322,0.0003185193,0.0001043025,0.00003411074,0.0003404472,0.00001642031,0.00008348946,0.0004594312,0.9570717,0.0007300962,0.0000212618,0.04037371],"study_design_scores_gemma":[0.003227203,0.005191928,0.0004172758,0.00005343305,0.0001101244,0.00001781278,0.00007058412,0.001230789,0.9840206,0.000415404,0.004836622,0.0004082423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782361,0.004802877,0.01271962,0.002170131,0.00003938855,0.001858557,0.00007573743,0.0000286486,0.0000689054],"genre_scores_gemma":[0.9936212,0.001360102,0.00314162,0.0008579781,0.0001559258,0.0004449135,0.00009324998,0.00007107316,0.0002539724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03996546,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02672840169013674,"score_gpt":0.3180621902871511,"score_spread":0.2913337885970144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}