{"id":"W2007520044","doi":"10.1016/j.aquatox.2011.11.006","title":"Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol","year":2011,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"King Saud University; Canada Research Chairs; State Key Laboratory of Freshwater Ecology and Biotechnology; State Key Laboratory in Marine Pollution; Western Economic Diversification Canada; Chinese Academy of Sciences; U.S. Environmental Protection Agency","keywords":"Internal medicine; Endocrinology; Zebrafish; Aromatase; Biology; Vitellogenin; In vivo; Testosterone (patch); Cytochrome P450; Danio; Endocrine system; Hormone; Leydig cell; In vitro; Gene expression; Gene; Metabolism; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006495424,0.0001686294,0.0003521665,0.0003303986,0.000009562017,0.000003245492,0.0001110282,0.0002599019,0.00008508427],"category_scores_gemma":[0.00053035,0.000166515,0.00002690268,0.0002787109,0.0001892522,0.00001333627,0.00004988906,0.0001914174,0.000002910564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000698908,"about_ca_system_score_gemma":0.00007343524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008111941,"about_ca_topic_score_gemma":0.005861534,"domain_scores_codex":[0.9981921,0.0004291818,0.0005270764,0.0004550106,0.0000658817,0.0003307353],"domain_scores_gemma":[0.9994717,0.00009450808,0.0001365428,0.0002445941,0.00001486679,0.00003773819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001093287,0.000586963,0.2084839,0.00002126255,0.000005295341,0.00001186575,0.0002274355,0.00003309072,0.7886695,0.00002270956,0.0000480243,0.000796718],"study_design_scores_gemma":[0.002883381,0.0007665408,0.3542337,0.00002083881,0.000005194649,0.00000417173,0.0002899595,0.0004443205,0.6405389,0.0004939849,0.0001592217,0.0001597395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977521,0.0005059962,0.0002490953,0.0001941231,0.0001076269,0.000388704,0.00000728534,0.000003388382,0.0007916777],"genre_scores_gemma":[0.9992629,0.0000822086,0.0002060857,0.0002157231,0.00002126035,0.00007029658,0.00003647355,0.0000123635,0.00009263289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1481305,"threshold_uncertainty_score":0.6790285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264517763495106,"score_gpt":0.23505935206736,"score_spread":0.2224141744324089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}