{"id":"W2007520044","doi":"10.1016/j.aquatox.2011.11.006","title":"Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol","year":2011,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"King Saud University; Canada Research Chairs; State Key Laboratory of Freshwater Ecology and Biotechnology; State Key Laboratory in Marine Pollution; Western Economic Diversification Canada; Chinese Academy of Sciences; U.S. Environmental Protection Agency","keywords":"Internal medicine; Endocrinology; Zebrafish; Aromatase; Biology; Vitellogenin; In vivo; Testosterone (patch); Cytochrome P450; Danio; Endocrine system; Hormone; Leydig cell; In vitro; Gene expression; Gene; Metabolism; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004510222,0.0007750191,0.0003703049,0.0006035488,0.0004363602,0.0003838505,0.0004580576,0.0005014765,0.002288009],"category_scores_gemma":[0.0001571666,0.0005184181,0.000791848,0.0004047629,0.0006417215,0.0004289843,0.000355874,0.001087871,0.0005957576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009295329,"about_ca_system_score_gemma":0.0006322017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009641635,"about_ca_topic_score_gemma":0.01557144,"domain_scores_codex":[0.999563,0.00007883129,0.00004714249,0.00009042966,0.0001189208,0.0001016136],"domain_scores_gemma":[0.9997651,0.00004509612,0.00005316126,0.00004988145,0.00004327346,0.00004351203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004337492,0.00001600151,0.00009826618,0.00001377921,0.000003753988,0.0000361639,0.00001924234,0.00003176125,0.9995455,0.00003743144,0.00002368145,0.0001309308],"study_design_scores_gemma":[0.000008591886,0.0001255226,0.001857477,0.000001610577,0.00001168933,0.00005440223,0.00002567918,0.0002265971,0.9971495,0.00001189942,0.0005228115,0.000004293619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836854,0.001000603,0.009344853,0.0002819119,0.00007995625,0.00009717846,0.001529038,0.000209646,0.003771423],"genre_scores_gemma":[0.9727658,0.001392094,0.006694825,0.0001588111,0.00001646261,0.0001412593,0.002110327,0.00007423999,0.01664608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009641635,"threshold_uncertainty_score":0.01917106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264517763495106,"score_gpt":0.23505935206736,"score_spread":0.2224141744324089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}