{"id":"W2007533476","doi":"10.1371/journal.ppat.1003852","title":"The CD8-Derived Chemokine XCL1/Lymphotactin Is a Conformation-Dependent, Broad-Spectrum Inhibitor of HIV-1","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemokine; CCL5; Chemokine receptor; CD8; Cell biology; Chemistry; CXC chemokine receptors; Biology; Cytotoxic T cell; Immunology; In vitro; Biochemistry; Immune system; IL-2 receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000126101,0.0001754919,0.0002397795,0.00006816995,0.0002930917,0.00002533397,0.0002400695,0.0001413766,0.00284293],"category_scores_gemma":[0.00009495264,0.0001151644,0.0001134816,0.0001097671,0.0002007954,0.0001175333,0.000106312,0.000185036,0.009362835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006478538,"about_ca_system_score_gemma":0.00009704586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001272875,"about_ca_topic_score_gemma":0.00002504035,"domain_scores_codex":[0.9987465,0.000113077,0.0003504538,0.000205251,0.00009869073,0.0004859978],"domain_scores_gemma":[0.9990597,0.0001787687,0.0001583933,0.0004142726,0.0001358833,0.00005296153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008691962,0.0002748597,0.003927929,0.00001972665,0.0004480515,0.000005472298,0.0009501604,4.188408e-7,0.9752007,0.0001009472,0.01583295,0.003151896],"study_design_scores_gemma":[0.002111346,0.0002238934,0.00999151,0.0000236958,0.00005014196,0.0000372644,0.0006294605,0.0000205904,0.9725941,0.0001345802,0.01402657,0.0001568275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907421,0.001139288,0.00002226868,0.002188064,0.0001601957,0.0006675128,0.0005226332,0.00005498407,0.004502926],"genre_scores_gemma":[0.9946166,0.0003584039,0.00004495075,0.0001133271,0.00003766161,0.0001517217,0.000243006,0.0000164807,0.004417847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006519906,"threshold_uncertainty_score":0.9980686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265632232459867,"score_gpt":0.2242507483531477,"score_spread":0.2115944260285491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}