{"id":"W2007536208","doi":"10.1038/cddis.2011.25","title":"SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"Royal Society of Canada; Canadian Institutes of Health Research; Royal Society; University of Ottawa; Howard Hughes Medical Institute","keywords":"Apoptosis; Downregulation and upregulation; Flip; Cell biology; Biology; Tumor necrosis factor alpha; Programmed cell death; Caspase 8; Kinase; Repressor; Caspase 2; Caspase; Biochemistry; Transcription factor; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005966716,0.0001571614,0.0001100946,0.0000307808,0.0001112918,0.00002781223,0.00006227712,0.000104299,0.00002745729],"category_scores_gemma":[0.00001150691,0.0001406311,0.00004723054,0.00003586994,0.0000488211,0.000005205029,0.00007711011,0.00004137491,0.000003870446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004086107,"about_ca_system_score_gemma":0.00003008266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003568321,"about_ca_topic_score_gemma":0.000001503106,"domain_scores_codex":[0.9992341,0.00002904545,0.0001251454,0.0003458152,0.00007318348,0.0001926755],"domain_scores_gemma":[0.9992418,0.000004076457,0.00004666063,0.0002264321,0.00002848782,0.0004525523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002255298,0.0001457876,0.00517685,0.00007109937,0.00002370879,0.000002722538,0.00007549025,5.566523e-7,0.9882832,0.0003498655,0.001664158,0.003981044],"study_design_scores_gemma":[0.002981299,0.0007135973,0.07681948,0.00003866585,0.0003415546,0.00001005247,0.0001307244,0.0006029197,0.8948111,0.005216475,0.01734826,0.0009858474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935312,0.003594716,0.0003643016,0.00003673199,0.00008310864,0.0001523121,0.00002352471,0.00001427094,0.0021998],"genre_scores_gemma":[0.9971757,0.0006802386,0.0003406343,0.0002181808,0.00005552336,0.00001223499,0.0001664997,0.00001894568,0.001332041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09347207,"threshold_uncertainty_score":0.573477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393638647743243,"score_gpt":0.2065548427649515,"score_spread":0.1926184562875191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}