{"id":"W2007536208","doi":"10.1038/cddis.2011.25","title":"SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"Royal Society of Canada; Canadian Institutes of Health Research; Royal Society; University of Ottawa; Howard Hughes Medical Institute","keywords":"Apoptosis; Downregulation and upregulation; Flip; Cell biology; Biology; Tumor necrosis factor alpha; Programmed cell death; Caspase 8; Kinase; Repressor; Caspase 2; Caspase; Biochemistry; Transcription factor; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001239312,0.0002760289,0.0001905548,0.0002162841,0.0001089766,0.000214463,0.0001375042,0.00024001,0.0007695361],"category_scores_gemma":[0.00007738904,0.00009526236,0.0001209669,0.000112448,0.0002121312,0.0001327435,0.0001455222,0.0003386372,0.0002784185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003885881,"about_ca_system_score_gemma":0.0001949642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003220872,"about_ca_topic_score_gemma":0.0006670287,"domain_scores_codex":[0.9999057,0.00001800511,0.000006652138,0.00001211752,0.0000205982,0.0000368242],"domain_scores_gemma":[0.9999275,0.000008268887,0.00002826526,0.000005375159,0.000009120636,0.00002146005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001192256,0.00001575343,0.0001845094,0.00002116919,0.000002126513,0.00003021976,0.000006414951,0.00004227174,0.9988739,0.0001103887,0.00002360769,0.0005703435],"study_design_scores_gemma":[0.00002370299,0.0002618457,0.008345407,0.000005278442,0.0000109529,0.0001607501,0.00002902606,0.0007582051,0.9878529,0.00007409457,0.002474694,0.000003204018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926941,0.003832545,0.001346802,0.0001143321,0.0000225174,0.00002774768,0.0001817494,0.00005738115,0.001722797],"genre_scores_gemma":[0.9957525,0.001370357,0.0008568014,0.00005678318,0.000007727422,0.00003737221,0.0002866997,0.000008477635,0.001623342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007695361,"threshold_uncertainty_score":0.002819479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393638647743243,"score_gpt":0.2065548427649515,"score_spread":0.1926184562875191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}