{"id":"W2007572328","doi":"10.1083/jcb.149.2.447","title":"Activated <i>ras</i> Prevents Downregulation of Bcl-XL Triggered by Detachment from the Extracellular Matrix","year":2000,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Anoikis; Downregulation and upregulation; Cell biology; Biology; Kinase; Extracellular matrix; Apoptosis; Cancer research; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005300769,0.0001301791,0.0002007034,0.00001978676,0.00007929552,0.0000072146,0.0003045525,0.0001799482,0.0002716374],"category_scores_gemma":[0.00001519797,0.0000688785,0.0001350486,0.00006697866,0.00008574082,0.000005408463,0.00003191879,0.0001218388,0.000004648216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001230385,"about_ca_system_score_gemma":0.00004323077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003748684,"about_ca_topic_score_gemma":0.000003127909,"domain_scores_codex":[0.9987965,0.0003500064,0.0004606057,0.0001181283,0.0001222191,0.0001525569],"domain_scores_gemma":[0.9990506,0.00006596737,0.0004743419,0.0002695344,0.00009864141,0.00004095487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004769692,0.00008659249,0.00003885723,0.00000351699,0.00008605383,4.180386e-7,0.00007685507,0.0004509454,0.986644,0.0000131663,0.001038467,0.01108416],"study_design_scores_gemma":[0.0008870559,0.0004038571,0.0005914596,0.00001158913,0.000113264,0.00001415816,0.00005226327,0.00009390499,0.9461548,0.0004928446,0.05110153,0.00008326161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854783,0.01198407,0.001812415,0.0002545219,0.0001175383,0.0001780533,0.00002652793,0.000002417023,0.0001461925],"genre_scores_gemma":[0.9941717,0.002946853,0.0002588204,0.00006450224,0.0001890113,0.000001528234,0.0001155642,0.00001176033,0.002240221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05006306,"threshold_uncertainty_score":0.297424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005244613743137201,"score_gpt":0.2306570569460273,"score_spread":0.2254124432028901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}