{"id":"W2007607510","doi":"10.1038/cr.2009.42","title":"Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling","year":2009,"lang":"en","type":"article","venue":"Cell Research","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Key Research and Development Program of China; Higher Education Discipline Innovation Project; Nanjing University; National Natural Science Foundation of China; University of Alberta; Vanderbilt University","keywords":"PTEN; Insulin resistance; Endocrinology; Internal medicine; Biology; Protein kinase B; Pancreas; Streptozotocin; PI3K/AKT/mTOR pathway; Diabetes mellitus; Phosphorylation; Signal transduction; Medicine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002804577,0.001244152,0.0006334526,0.001207437,0.0002909656,0.0007170451,0.0006220206,0.0006028638,0.004723697],"category_scores_gemma":[0.0005034553,0.0006224414,0.0006617088,0.0007464998,0.001086874,0.000545838,0.0006535959,0.001558078,0.0008099245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061414,"about_ca_system_score_gemma":0.0004555968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006472301,"about_ca_topic_score_gemma":0.0006379997,"domain_scores_codex":[0.999582,0.00005422052,0.00006712238,0.00009733194,0.0001160812,0.0000832841],"domain_scores_gemma":[0.999449,0.0001096232,0.0001466785,0.00008090217,0.00001862562,0.0001952292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001283476,0.0001329165,0.0007412064,0.00007181611,0.00005933817,0.0009893408,0.00002206551,0.00036448,0.9931686,0.0005688951,0.0001915777,0.002406275],"study_design_scores_gemma":[0.0003874368,0.0007979187,0.01047571,0.00001779047,0.0001947868,0.006397547,0.0000931055,0.002577301,0.9750473,0.0009229258,0.003052381,0.00003576852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989981,0.0006799254,0.004188502,0.0004423119,0.0000972807,0.00005128929,0.001600207,0.0005417944,0.002417659],"genre_scores_gemma":[0.9947481,0.0005072452,0.001512386,0.00008402796,0.00001965847,0.00004032451,0.0007302018,0.000118597,0.002239386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004723697,"threshold_uncertainty_score":0.01580232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05675918671745439,"score_gpt":0.3253920973016782,"score_spread":0.2686329105842238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}