{"id":"W2007608341","doi":"10.1074/jbc.m108266200","title":"In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease; NS2-3 protease; Cleavage (geology); Biochemistry; Chemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004613374,0.00009727147,0.0004845046,0.00007523461,0.00001068183,0.00000445492,0.0001330826,0.0001947052,0.0007914384],"category_scores_gemma":[0.0009332051,0.00006829881,0.0001249455,0.0002527485,0.0001108361,0.00006635355,0.00003834808,0.0003577762,0.000003133999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007478627,"about_ca_system_score_gemma":0.0001640359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007473453,"about_ca_topic_score_gemma":0.000001121346,"domain_scores_codex":[0.9985669,0.00006938304,0.0007473237,0.000114903,0.0003233964,0.0001780788],"domain_scores_gemma":[0.9989446,0.00006063668,0.0004450262,0.0001411546,0.0002837702,0.0001247495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00150744,0.0004731453,0.0433773,0.0001403904,0.00003075564,0.0007848258,0.00002940234,3.897675e-7,0.9507387,0.00000252839,0.0000218184,0.00289335],"study_design_scores_gemma":[0.001089092,0.0003394913,0.06695041,0.0001608961,0.00001279594,0.0002947066,0.000007308288,0.00005354066,0.9301238,0.00006108429,0.0008492789,0.00005758691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983304,0.00008049805,0.0001441751,0.0004558194,0.00002648905,0.0001659523,0.00003666149,0.000003792152,0.0007562566],"genre_scores_gemma":[0.9978544,0.001342548,0.0004228094,0.00007491708,0.0001535822,0.00000636803,0.0000209079,0.000006714991,0.000117749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02357311,"threshold_uncertainty_score":0.8665696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03813092835127316,"score_gpt":0.3056986533377042,"score_spread":0.267567724986431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}