{"id":"W2007613133","doi":"10.1016/j.devcel.2011.06.022","title":"Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase","year":2011,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Autocrine signalling; Atrioventricular canal; Cell biology; Soluble guanylyl cyclase; Guanylate cyclase; Mesenchymal stem cell; Internal medicine; Endocrinology; Biochemistry; Receptor; Nitric oxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692871,0.0001303577,0.0001391822,0.000215182,0.0002017536,0.0004640088,0.0001519806,0.0002423287,0.001036944],"category_scores_gemma":[0.0002022031,0.0001434119,0.0001521994,0.00007171807,0.0002787694,0.0003783372,0.0003737486,0.0006715418,0.0002912012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004824074,"about_ca_system_score_gemma":0.0002525821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009144024,"about_ca_topic_score_gemma":0.002455705,"domain_scores_codex":[0.9998733,0.00002415828,0.000009038447,0.00002140146,0.00003914693,0.00003295767],"domain_scores_gemma":[0.9998765,0.00002570335,0.00002297801,0.00001460017,0.00001999182,0.00004009815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372716,0.000007885977,0.0005134225,0.00002304393,0.000002584096,0.0002297915,0.00004472894,0.00007648896,0.9948767,0.002062576,0.00008164695,0.001943833],"study_design_scores_gemma":[0.00004652442,0.0001075383,0.01432591,0.00001405636,0.00001532645,0.0004991565,0.0002351053,0.002549123,0.9756463,0.0008857879,0.00566758,0.000007562002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873183,0.001981907,0.005405759,0.0003024497,0.00006708415,0.00002332155,0.0002353446,0.00006602875,0.004599687],"genre_scores_gemma":[0.9933146,0.0005877635,0.001587868,0.00005002898,0.00002101528,0.00001017337,0.000132149,0.00001456868,0.004281882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036944,"threshold_uncertainty_score":0.003500164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0302442699588145,"score_gpt":0.2581092821537481,"score_spread":0.2278650121949336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}