{"id":"W2007695631","doi":"10.1007/s10637-013-9990-3","title":"Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial","year":2013,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Royal Marsden NHS Foundation Trust; GlaxoSmithKline; Amgen","keywords":"Medicine; Irinotecan; Oxaliplatin; Colorectal cancer; Toxicity; Internal medicine; Gastroenterology; Phases of clinical research; Surgery; Cancer; Progression-free survival; Dexamethasone; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008360206,0.0008227018,0.00120745,0.0002571989,0.0001948696,0.0008606115,0.000668993,0.0005787255,0.00277444],"category_scores_gemma":[0.0009300701,0.0002085291,0.0009309899,0.0004080124,0.0004841794,0.0006601655,0.000223589,0.002524143,0.0004644576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006513281,"about_ca_system_score_gemma":0.0007514274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118432,"about_ca_topic_score_gemma":0.003385651,"domain_scores_codex":[0.9997794,0.000114792,0.000009194613,0.00003003737,0.00002267733,0.00004391192],"domain_scores_gemma":[0.9994271,0.0001520663,0.0001258205,0.0000403004,0.00002507442,0.0002297006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7803997,0.007353323,0.01127618,0.001657795,0.00313652,0.0003379991,0.0001654206,0.002228694,0.01651148,0.000364264,0.005684712,0.1708839],"study_design_scores_gemma":[0.7545888,0.1812866,0.04836982,0.0001688955,0.00285012,0.0006469126,0.0001366261,0.001701776,0.003501449,0.0004292099,0.006250416,0.00006928695],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837782,0.01029856,0.0001960514,0.001141205,0.000171507,0.0003355172,0.001083506,0.00006339644,0.002932048],"genre_scores_gemma":[0.9863417,0.007499316,0.0004351758,0.0009409937,0.0001815809,0.0002390023,0.001974931,0.00002002982,0.002367334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277444,"threshold_uncertainty_score":0.009281456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849474570922308,"score_gpt":0.2794462099801454,"score_spread":0.2609514642709223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}