{"id":"W2007695631","doi":"10.1007/s10637-013-9990-3","title":"Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial","year":2013,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Royal Marsden NHS Foundation Trust; GlaxoSmithKline; Amgen","keywords":"Medicine; Irinotecan; Oxaliplatin; Colorectal cancer; Toxicity; Internal medicine; Gastroenterology; Phases of clinical research; Surgery; Cancer; Progression-free survival; Dexamethasone; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000932316,0.0001878715,0.0003551579,0.00007848522,0.00009836766,0.00001063456,0.00008764054,0.00003810668,0.0001055858],"category_scores_gemma":[0.0001914826,0.0001078831,0.00007126875,0.0004445422,0.0002173965,0.0001021885,0.00005438861,0.0001503107,0.000003623654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128129,"about_ca_system_score_gemma":0.0007393004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592978,"about_ca_topic_score_gemma":0.0005049887,"domain_scores_codex":[0.998445,0.00006595496,0.0004608197,0.0002658663,0.0005655789,0.0001967437],"domain_scores_gemma":[0.9990568,0.0001032011,0.0002348524,0.0001489922,0.0003098811,0.0001462614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3798333,0.01385387,0.3829402,0.0002394548,0.002393506,0.00001847839,0.018333,0.0002976376,0.001302324,0.0009756385,0.04210991,0.1577027],"study_design_scores_gemma":[0.252943,0.01170168,0.7292507,0.0004716939,0.0002735569,0.000001608789,0.0001240649,0.0002086643,0.00320436,0.001026261,0.0005879519,0.0002065245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925952,0.0001929981,0.00000118424,0.003909135,0.0001965737,0.002151623,0.0002014747,0.00001748772,0.0007343084],"genre_scores_gemma":[0.9983852,0.00001880562,0.0004130814,0.0002009734,0.0000708293,0.0002650378,0.0001384572,0.00001391094,0.0004936958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3463105,"threshold_uncertainty_score":0.4399347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849474570922308,"score_gpt":0.2794462099801454,"score_spread":0.2609514642709223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}