{"id":"W2007713019","doi":"10.1111/bjh.12303","title":"Ticlopidine‐associated <scp>ADAMTS</scp>13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (<scp>SONAR</scp>)","year":2013,"lang":"en","type":"letter","venue":"British Journal of Haematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Apheresis Group; London Health Sciences Centre","funders":"Centers for Disease Control and Prevention; National Cancer Institute; National Heart, Lung, and Blood Institute; Takeda Science Foundation","keywords":"ADAMTS13; Thrombotic thrombocytopenic purpura; Ticlopidine; Von Willebrand factor; Medicine; ADAMTS; Microangiopathic hemolytic anemia; Internal medicine; Platelet; Thrombospondin; Immunology; Metalloproteinase; Clopidogrel; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001516755,0.0007669442,0.002820204,0.0004424908,0.0004757708,0.0001280343,0.001351332,0.001740271,0.0006299693],"category_scores_gemma":[0.003391014,0.0007227744,0.000795675,0.0005999526,0.0005681617,0.0002494759,0.0003673268,0.005485718,0.0005988205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006926307,"about_ca_system_score_gemma":0.0006640172,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007599664,"about_ca_topic_score_gemma":0.007781413,"domain_scores_codex":[0.9912155,0.003385871,0.002436872,0.0009566185,0.0003882609,0.001616936],"domain_scores_gemma":[0.9885176,0.006664977,0.003509302,0.0008767428,0.0003398765,0.00009151112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002243427,0.0006548545,0.02825701,0.00007916653,0.001158886,0.03306226,0.0008979259,0.0001932034,0.0004602999,0.00002077296,0.9350234,0.0001698319],"study_design_scores_gemma":[0.007616916,0.0007029884,0.3547119,0.007592596,0.001479419,0.2200205,0.01253554,0.00004902544,0.0001602423,0.001258917,0.3932152,0.000656729],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709468,0.007688688,0.00001605569,0.01553855,0.003062384,0.001351464,0.0005965318,0.0000677149,0.0007317872],"genre_scores_gemma":[0.9764123,0.0004957537,0.00004789188,0.01752701,0.0008887812,0.0002191859,0.0008687105,0.0001734783,0.003366869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5418082,"threshold_uncertainty_score":0.9995557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02237153780491967,"score_gpt":0.2437855264337852,"score_spread":0.2214139886288656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}