{"id":"W2007765039","doi":"10.1038/nature13283","title":"The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; BioPhage Pharma (Canada); Hamilton Health Sciences; Hôpital Maisonneuve-Rosemont; Jewish General Hospital; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Drug resistance; Medicine; Drug; Pharmacology; GLI1; Cancer research; Oncology; Internal medicine; Biology; Hedgehog; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002623759,0.0001712863,0.0001263329,0.00001322765,0.0003711113,0.00005464967,0.0002995062,0.0005644742,0.000008202119],"category_scores_gemma":[0.0004296394,0.0001211254,0.00008070969,0.0001079158,0.00009417097,0.000006254622,0.0001082732,0.000672148,0.00003397958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002384198,"about_ca_system_score_gemma":0.00006280473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003205646,"about_ca_topic_score_gemma":0.0002136162,"domain_scores_codex":[0.9988623,0.0001040482,0.0001633862,0.0003714388,0.000192612,0.0003062002],"domain_scores_gemma":[0.9991374,0.00005977313,0.0000955946,0.0005319538,0.0001329041,0.00004238481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000258151,0.00009870162,0.003306048,0.0001001705,0.0002633608,0.000003749249,0.001296572,0.0000543613,0.6209467,0.005080515,0.3634164,0.005175231],"study_design_scores_gemma":[0.0002234842,0.00003272515,0.001730633,0.0000160388,0.000008482726,0.000001161568,0.00006135976,0.000006200535,0.2843298,0.0005190846,0.7129235,0.0001476151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732519,0.01409847,0.0005518611,0.003125963,0.0008440227,0.0002395666,0.00002025653,0.00004694981,0.007821044],"genre_scores_gemma":[0.9925843,0.0003356136,0.000294456,0.000829611,0.0005653352,0.00002059048,0.00005127309,0.00002481162,0.005293963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.349507,"threshold_uncertainty_score":0.493935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008754466265208786,"score_gpt":0.2660719503757946,"score_spread":0.2573174841105859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}