{"id":"W2007777043","doi":"10.1007/s00253-011-3511-0","title":"End-product induced metabolic shifts in Clostridium thermocellum ATCC 27405","year":2011,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Ferredoxin; Clostridium thermocellum; Biochemistry; Fermentation; Mixed acid fermentation; Cellobiose; Chemistry; Catabolism; Metabolism; Product inhibition; Hydrogenase; Oxidoreductase; Clostridium beijerinckii; Bioconversion; Enzyme; Ethanol; Biology; Bacteria; Lactic acid fermentation; Lactic acid; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003230927,0.00029348,0.0003434907,0.0002221386,0.00006803059,0.000005840076,0.0002734446,0.000847928,0.0000456734],"category_scores_gemma":[0.00003954053,0.0002643749,0.0000520569,0.0002643416,0.0003291378,0.000003691017,0.0002151146,0.0003756986,0.00002976895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009281911,"about_ca_system_score_gemma":0.00004017029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008710663,"about_ca_topic_score_gemma":0.00008713539,"domain_scores_codex":[0.9982873,0.00004593003,0.000304727,0.0007894542,0.00002317601,0.0005493942],"domain_scores_gemma":[0.9993345,0.000003532268,0.00009404183,0.0004895516,0.00002411485,0.0000542664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157741,0.00008517729,0.0002735787,0.00001119879,0.00005361198,0.000003267251,0.00006283771,4.701327e-7,0.9848915,0.00372604,0.0001494623,0.01062712],"study_design_scores_gemma":[0.0005415574,0.0001390358,0.002021495,0.000004529451,0.00002206271,0.0001017591,0.00004395434,4.571275e-7,0.9573615,0.0001747241,0.03929178,0.0002971053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954169,0.002751381,0.0001288318,0.000351951,0.0003957556,0.0003020013,0.00001704069,0.00008037399,0.0005558116],"genre_scores_gemma":[0.9969438,0.001195817,0.001193416,0.000214884,0.0002044245,0.00003431937,0.00009456404,0.00002796667,0.00009079151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03914232,"threshold_uncertainty_score":0.9999809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016166544551971,"score_gpt":0.1905316420984141,"score_spread":0.1803699766528944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}