{"id":"W2007777043","doi":"10.1007/s00253-011-3511-0","title":"End-product induced metabolic shifts in Clostridium thermocellum ATCC 27405","year":2011,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Ferredoxin; Clostridium thermocellum; Biochemistry; Fermentation; Mixed acid fermentation; Cellobiose; Chemistry; Catabolism; Metabolism; Product inhibition; Hydrogenase; Oxidoreductase; Clostridium beijerinckii; Bioconversion; Enzyme; Ethanol; Biology; Bacteria; Lactic acid fermentation; Lactic acid; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314873,0.0006006603,0.0004070782,0.0003652988,0.0003364673,0.0005097541,0.0004583749,0.0004134146,0.0009759556],"category_scores_gemma":[0.0003753404,0.0002320131,0.0003887322,0.0006320595,0.0002312051,0.0002717745,0.00046383,0.0006570106,0.0003619517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007493696,"about_ca_system_score_gemma":0.0009015203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0124144,"about_ca_topic_score_gemma":0.008748849,"domain_scores_codex":[0.9994506,0.00007223157,0.00005263831,0.00008218723,0.0001991189,0.0001431516],"domain_scores_gemma":[0.9997173,0.00005658813,0.00005082546,0.00004178644,0.00007651439,0.00005697162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003608344,0.00008256411,0.0003702551,0.00002115744,0.000006310431,0.00007679487,0.00003209736,0.0001511452,0.9975618,0.00005945367,0.00005373026,0.001223863],"study_design_scores_gemma":[0.00001822728,0.0004442494,0.009787603,0.000005767022,0.00002067315,0.0001296312,0.0001158669,0.0008282951,0.9878557,0.00005662637,0.0007203813,0.00001688336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977308,0.0001610393,0.0005747446,0.00006564496,0.00002450703,0.00001401227,0.0008063031,0.00002722534,0.0005957077],"genre_scores_gemma":[0.9930261,0.0001578095,0.001217431,0.00004566192,0.000008621089,0.00003064299,0.002984654,0.00004371984,0.002485398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0124144,"threshold_uncertainty_score":0.02468425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016166544551971,"score_gpt":0.1905316420984141,"score_spread":0.1803699766528944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}