{"id":"W2007788206","doi":"10.1016/j.tox.2011.11.006","title":"Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: A role of heme oxygenase","year":2011,"lang":"en","type":"article","venue":"Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Heme; Heme oxygenase; Cytochrome P450; Chemistry; Hemin; Gene expression; Aryl hydrocarbon receptor nuclear translocator; Messenger RNA; Transfection; Regulation of gene expression; Enzyme inducer; Cytochrome; Molecular biology; Biochemistry; Enzyme; Gene; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104844,0.0002269114,0.0002275262,0.0001937005,0.0002625953,0.0003965088,0.00009718442,0.0001717169,0.00132586],"category_scores_gemma":[0.0001321182,0.0001526192,0.0002501204,0.000206791,0.000327022,0.0002531631,0.0001484225,0.0003686527,0.0003140162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003582368,"about_ca_system_score_gemma":0.0002410137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001765823,"about_ca_topic_score_gemma":0.002311844,"domain_scores_codex":[0.9999015,0.00002003598,0.000005992117,0.00001948939,0.00001945062,0.00003360114],"domain_scores_gemma":[0.9999092,0.00002786435,0.00001585726,0.00001452848,0.00001620081,0.00001634674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005615107,0.00003985617,0.000660762,0.00002705219,0.000004978324,0.00006355255,0.00005302833,0.00005224705,0.9973604,0.0001964388,0.00004652873,0.0009335337],"study_design_scores_gemma":[0.00004486613,0.0002670512,0.02387585,0.000005687288,0.00003235102,0.0002207877,0.0001886103,0.0009386551,0.972795,0.0002201231,0.001400113,0.00001090169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993724,0.001431951,0.002545041,0.000334207,0.00005403282,0.00001703045,0.000499453,0.00007738981,0.001316965],"genre_scores_gemma":[0.9956883,0.0005254045,0.0007036129,0.00003772652,0.0000165352,0.00001674232,0.000456171,0.00001444366,0.002541172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765823,"threshold_uncertainty_score":0.00443542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422063468984622,"score_gpt":0.2045689863937705,"score_spread":0.1903483517039243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}