{"id":"W2007788410","doi":"10.1242/jcs.102061","title":"Polycomb repressive complex 2 impedes intestinal cell terminal differentiation","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"PRC2; Biology; Cellular differentiation; Cell biology; Polycomb-group proteins; Stem cell; Epigenetics; Embryonic stem cell; Population; Gene knockdown; Cell culture; Genetics; Gene expression; Histone H3; Repressor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008482,0.0003652652,0.000339919,0.0002634708,0.0001663748,0.0004430185,0.0003677035,0.0003934526,0.002672262],"category_scores_gemma":[0.0001925094,0.0002341903,0.0002766082,0.0001890062,0.0003916779,0.0002686183,0.0003726823,0.0009323676,0.0004602897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039058,"about_ca_system_score_gemma":0.0003587325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086866,"about_ca_topic_score_gemma":0.00239984,"domain_scores_codex":[0.9996941,0.00004205697,0.0000398546,0.00006391216,0.00008649632,0.00007366818],"domain_scores_gemma":[0.9998173,0.00004592205,0.00003601381,0.00002877568,0.0000140674,0.00005799569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342732,0.00004702693,0.000105593,0.00005813639,0.000006884803,0.00002829933,0.00001666683,0.00008284886,0.9983137,0.0002007484,0.00008363213,0.0009222669],"study_design_scores_gemma":[0.00003221942,0.0002712119,0.002399808,0.000004969565,0.00001566719,0.00008500254,0.00002596254,0.001951006,0.9911617,0.000052307,0.003995297,0.000004761937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874203,0.001817839,0.006225259,0.0002536172,0.0001274663,0.00007638797,0.0008112863,0.0003019751,0.002965901],"genre_scores_gemma":[0.9908082,0.0007761052,0.002165408,0.00007839476,0.00001496534,0.00007732641,0.0005800721,0.00004562864,0.005453843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002672262,"threshold_uncertainty_score":0.008939564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172182868858616,"score_gpt":0.2835844632762018,"score_spread":0.2663661763903402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}