{"id":"W2007791827","doi":"10.1073/pnas.102657399","title":"β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":313,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Mesenchymal stem cell; Catenin; Wound healing; Cancer research; Biology; Genetically modified mouse; Fibroblast; Aggressive fibromatosis; Transgene; Pathology; Fibromatosis; Wnt signaling pathway; Immunology; Cell biology; Medicine; Signal transduction; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287903,0.00008895623,0.00009860585,0.00005731072,0.0001742468,0.00003781368,0.0001434749,0.00008250726,0.000007172114],"category_scores_gemma":[0.0002748335,0.00006427066,0.00001501304,0.0001702014,0.0006695112,0.00002742468,0.0001252717,0.00004347853,1.072122e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006781758,"about_ca_system_score_gemma":0.00001779795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000191034,"about_ca_topic_score_gemma":2.144911e-7,"domain_scores_codex":[0.9991676,0.000007499927,0.000178869,0.0002405372,0.0003113795,0.00009416392],"domain_scores_gemma":[0.9994802,0.00004320464,0.000232762,0.000006550841,0.0002071721,0.00003005193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001500551,0.0000215595,0.1427265,0.000129356,0.00001467852,1.302463e-8,0.0003083656,0.00006680774,0.8560837,0.0002590985,0.0001686517,0.0002063143],"study_design_scores_gemma":[0.0001765919,0.00008225412,0.04327194,0.00007033259,0.0000159728,0.00004983996,0.0001278094,0.001230233,0.9519425,0.002911363,0.00003124234,0.0000898922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979936,0.001268295,0.000001505252,0.0003922669,0.000008866728,0.0001243921,0.00000789334,0.0000034806,0.000199665],"genre_scores_gemma":[0.9989339,0.0004183021,0.0004096343,0.00005273894,0.0000304283,0.000009603813,6.157633e-7,0.000003872453,0.0001409235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09945453,"threshold_uncertainty_score":0.2620881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223981457888123,"score_gpt":0.2448496239670014,"score_spread":0.2224514781781891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}