{"id":"W2007820468","doi":"10.1021/ja010088w","title":"Dihydroceramide Δ<sup>4</sup> Desaturase Initiates Substrate Oxidation at C-4","year":2001,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Chemistry; Kinetic isotope effect; Bond cleavage; Substrate (aquarium); Deuterium; Double bond; Stereochemistry; Mass spectrometry; Enzyme; Cleavage (geology); Chromatography; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325143,0.0005769306,0.0003144194,0.0001920313,0.0001458234,0.0003520358,0.0002487722,0.0002640258,0.001203106],"category_scores_gemma":[0.0003481479,0.0002631886,0.0002572371,0.0001552371,0.0003368367,0.0002777726,0.000293665,0.000396264,0.0006898305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006427575,"about_ca_system_score_gemma":0.0004194613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001570046,"about_ca_topic_score_gemma":0.002658274,"domain_scores_codex":[0.999813,0.00003166023,0.0000100776,0.00005829788,0.00003765365,0.00004927203],"domain_scores_gemma":[0.9997253,0.00006000201,0.00007663104,0.00004200617,0.00004942286,0.00004656301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001888311,0.00000659382,0.001136927,0.00002454239,0.000008853396,0.00007867337,0.00001423107,0.00004088104,0.996874,0.0001190356,0.00001893829,0.001488423],"study_design_scores_gemma":[0.00000350157,0.00003872857,0.003083334,0.000001838951,0.000004343775,0.00008734628,0.00001634702,0.0001330479,0.9960299,0.0000389119,0.0005604572,0.00000231885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910976,0.001539706,0.004725627,0.0000906053,0.00003945954,0.00002363652,0.0003422478,0.00009376714,0.002047346],"genre_scores_gemma":[0.9943668,0.0005183119,0.002799586,0.00005496276,0.00001085966,0.0000117593,0.0005421341,0.00002788226,0.001667619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570046,"threshold_uncertainty_score":0.004663587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008904840348665857,"score_gpt":0.2332891509267317,"score_spread":0.2243843105780658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}