{"id":"W2007863280","doi":"10.1111/j.1471-4159.2004.02867.x","title":"Mutagenesis analysis of the serotonin 5‐HT2C receptor and a <i>Caenorhabditis elegans</i> 5‐HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist‐dependent activation of 5‐HT2 receptors","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Caenorhabditis elegans; Helix (gastropod); Mutagenesis; Serotonin; Biology; Agonist; Genetics; Conserved sequence; Serotonin Antagonists; Receptor; Mutation; Cell biology; 5-HT receptor; Gene; Base sequence; Zoology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006956,0.0005727425,0.0003419713,0.0002592853,0.0002130268,0.0002075233,0.000395513,0.0003782005,0.0006791435],"category_scores_gemma":[0.000214696,0.0002014151,0.0005859852,0.0001803197,0.0002285385,0.00008352193,0.0002402339,0.0003922117,0.0003630458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005799248,"about_ca_system_score_gemma":0.0004281466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00395134,"about_ca_topic_score_gemma":0.005200376,"domain_scores_codex":[0.9997736,0.00004365954,0.00002607251,0.00003703779,0.0000840424,0.00003557452],"domain_scores_gemma":[0.9998068,0.00003285888,0.00006914206,0.00001696134,0.00002904948,0.00004517592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001383891,0.00003499365,0.0002746273,0.0000381684,0.00002032853,0.0001736871,0.00002127325,0.0002316825,0.9982283,0.00008156194,0.000029554,0.0007274668],"study_design_scores_gemma":[0.00007765726,0.0005692762,0.01421323,0.00002455159,0.0001120642,0.0009563217,0.00007914966,0.004035799,0.976957,0.00004045442,0.002904958,0.00002956487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957515,0.0002561642,0.00234534,0.00004542962,0.00001962614,0.0001157522,0.0005266434,0.00003941412,0.0009001261],"genre_scores_gemma":[0.9926277,0.0003036603,0.004869577,0.00005978958,0.000009876347,0.00005834443,0.0008635327,0.00003484597,0.001172764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00395134,"threshold_uncertainty_score":0.007856667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006614040819738328,"score_gpt":0.2222578814589654,"score_spread":0.215643840639227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}