{"id":"W2007870253","doi":"10.1016/j.semcdb.2012.02.001","title":"Amino acid sensing and regulation of mTORC1","year":2012,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Department of Education, Heilongjiang Province; Alberta Cancer Foundation","keywords":"mTORC1; Amino acid; Autophagy; Protein biosynthesis; Biochemistry; Chemistry; Biosynthesis; Cell biology; Biology; Computational biology; Gene; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003495251,0.001014715,0.001238623,0.001060548,0.0001943035,0.001028269,0.0008902373,0.0007683684,0.001762165],"category_scores_gemma":[0.000223747,0.0002865854,0.0002794072,0.001295592,0.0005383788,0.0008224231,0.0007127975,0.001132943,0.00215063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006456167,"about_ca_system_score_gemma":0.0005848475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004206029,"about_ca_topic_score_gemma":0.0008107898,"domain_scores_codex":[0.9998828,0.00001266187,0.00001509299,0.00002827219,0.00004161625,0.00001948789],"domain_scores_gemma":[0.9999352,0.00002034132,0.00001484006,0.000003333113,0.00001545672,0.00001091657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002506158,0.00005710172,0.0001890327,0.009768493,0.0000973959,0.0004135619,0.00005218032,0.0006564035,0.03074265,0.006615735,0.02244159,0.9287152],"study_design_scores_gemma":[0.00004426331,0.00009023311,0.00224005,0.0008133276,0.0001266621,0.001207471,0.00006681732,0.0002602229,0.01181335,0.003189271,0.9801179,0.00003032137],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006745741,0.9960057,0.0003921431,0.000290075,0.0002939239,0.000005649933,0.0000432345,0.00002151447,0.002273175],"genre_scores_gemma":[0.004218098,0.9929166,0.0004394858,0.0002206925,0.0002943334,0.00001615054,0.000125502,0.000004970006,0.00176429],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001762165,"threshold_uncertainty_score":0.005894959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963334838153661,"score_gpt":0.2785665268321867,"score_spread":0.2589331784506501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}