{"id":"W2007872099","doi":"10.1371/journal.pgen.1000766","title":"Fine-Scale Variation and Genetic Determinants of Alternative Splicing across Individuals","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Genome Canada","keywords":"Minigene; Biology; RNA splicing; Alternative splicing; In silico; Genetics; Computational biology; Single-nucleotide polymorphism; splice; Enhancer; Transcriptome; Exon; Gene; Microarray; Gene expression; RNA; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008416297,0.0003021533,0.0003658412,0.001095538,0.0002519651,0.0003650845,0.0002249963,0.0003930632,0.001766422],"category_scores_gemma":[0.001396924,0.0002048541,0.0004627485,0.0005040089,0.0004236402,0.0001582763,0.0003410314,0.0004217994,0.0002830982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001018869,"about_ca_system_score_gemma":0.00006060914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003707721,"about_ca_topic_score_gemma":0.0005083421,"domain_scores_codex":[0.9987638,0.0003159176,0.0001051195,0.0005693911,0.0001678709,0.00007789974],"domain_scores_gemma":[0.9987864,0.0007252828,0.0001592282,0.0002315386,0.00005103875,0.00004653309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001190395,0.0001109322,0.3355429,0.00008328522,0.0007081479,0.001302225,0.001002548,0.001009662,0.6349992,0.0006106281,0.0001772255,0.02326271],"study_design_scores_gemma":[0.00001525352,0.0003680484,0.9711413,0.000008508962,0.0001758342,0.002347832,0.0001349842,0.001682249,0.02288999,0.0005231781,0.0006930882,0.00001963581],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964617,0.0001194954,0.002772452,0.00001607957,0.000005859121,0.00001003596,0.0002839142,0.00001917197,0.0003113828],"genre_scores_gemma":[0.9981112,0.00006039186,0.001356975,0.00001780937,0.000004785813,0.00001311086,0.0002327668,0.00002001269,0.0001828997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766422,"threshold_uncertainty_score":0.005909264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819115462511327,"score_gpt":0.3035120048316711,"score_spread":0.2853208502065578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}