{"id":"W2007872099","doi":"10.1371/journal.pgen.1000766","title":"Fine-Scale Variation and Genetic Determinants of Alternative Splicing across Individuals","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Genome Canada","keywords":"Minigene; Biology; RNA splicing; Alternative splicing; In silico; Genetics; Computational biology; Single-nucleotide polymorphism; splice; Enhancer; Transcriptome; Exon; Gene; Microarray; Gene expression; RNA; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105891,0.0001212347,0.0001570613,0.00003439169,0.00007009994,0.00002610398,0.0001589156,0.00009569294,0.000004073289],"category_scores_gemma":[0.0000641332,0.000118231,0.00003598338,0.00007000772,0.00005744063,0.000003358392,0.0001014411,0.00006409574,0.000002153206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007023716,"about_ca_system_score_gemma":0.00002959626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001532082,"about_ca_topic_score_gemma":0.00006269382,"domain_scores_codex":[0.9989893,0.00004213992,0.0002335733,0.0002621558,0.000194103,0.0002787505],"domain_scores_gemma":[0.9994465,0.00001438153,0.0001052447,0.0002450746,0.00009639875,0.00009241456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001921052,0.00005649973,0.07298078,0.00001877747,0.00002277825,0.000004003772,0.000333834,0.0001374313,0.9107959,0.000001979097,0.00001940486,0.01560939],"study_design_scores_gemma":[0.0003584212,0.0004208001,0.274543,0.00002200145,0.00001358476,0.00001046261,0.00002922792,0.004361528,0.7199677,0.0001193008,0.00004257651,0.0001113554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984615,0.0006172448,0.0005795939,0.00003696128,0.00002540126,0.0001809306,0.00003177925,0.000005050001,0.00006148856],"genre_scores_gemma":[0.9966573,0.0002789689,0.0027001,0.00006906378,0.0001228641,0.000005713649,0.00001219044,0.00001307337,0.0001407323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2015622,"threshold_uncertainty_score":0.4821322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819115462511327,"score_gpt":0.3035120048316711,"score_spread":0.2853208502065578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}