{"id":"W2007879037","doi":"10.1111/apt.12555","title":"Randomised clinical trial: individualised vs. weight‐based dosing of azathioprine in Crohn's disease","year":2013,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of North Carolina at Chapel Hill; Medical Center, University of Pittsburgh; National Institutes of Health; Hospital for Sick Children; University of Alberta; Crohn's and Colitis Foundation; London Health Sciences Centre; Johns Hopkins University; University of Pittsburgh; Crohn's and Colitis Foundation of America","keywords":"Medicine; Dosing; Thiopurine methyltransferase; Azathioprine; Internal medicine; Gastroenterology; Weight loss; Clinical trial; Crohn's disease; Surgery; Disease; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005691183,0.002023084,0.006782813,0.0007285043,0.000474635,0.001710892,0.001571118,0.004407371,0.01425414],"category_scores_gemma":[0.008776644,0.001039892,0.002747929,0.0007966248,0.001965469,0.00171508,0.0008802615,0.003899111,0.001451501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031774,"about_ca_system_score_gemma":0.001791662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009795075,"about_ca_topic_score_gemma":0.001575064,"domain_scores_codex":[0.9958722,0.002767447,0.0003484839,0.0005077191,0.0002430211,0.0002612064],"domain_scores_gemma":[0.9960763,0.001793112,0.000938975,0.0003601608,0.0002320242,0.0005993846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9931549,0.0009530794,0.00006135734,0.0006920013,0.0004688126,0.00001379263,0.00001843364,0.0001528365,0.0005878274,0.00007272161,0.0002282003,0.0035961],"study_design_scores_gemma":[0.9845511,0.0144827,0.0001842906,0.0000373512,0.0001969522,0.000009022266,0.000004128052,0.0001390444,0.00006188698,0.00009034032,0.0002369434,0.000006216355],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223861,0.02017185,0.004126826,0.003362023,0.007631251,0.03266294,0.002792591,0.0004497404,0.006416745],"genre_scores_gemma":[0.928332,0.007170323,0.00851741,0.003413182,0.00242356,0.03875409,0.001665398,0.00008099695,0.009642967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425414,"threshold_uncertainty_score":0.04768491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376615730857864,"score_gpt":0.3444898807615983,"score_spread":0.3107237234530196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}