{"id":"W2007879037","doi":"10.1111/apt.12555","title":"Randomised clinical trial: individualised vs. weight‐based dosing of azathioprine in Crohn's disease","year":2013,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of North Carolina at Chapel Hill; Medical Center, University of Pittsburgh; National Institutes of Health; Hospital for Sick Children; University of Alberta; Crohn's and Colitis Foundation; London Health Sciences Centre; Johns Hopkins University; University of Pittsburgh; Crohn's and Colitis Foundation of America","keywords":"Medicine; Dosing; Thiopurine methyltransferase; Azathioprine; Internal medicine; Gastroenterology; Weight loss; Clinical trial; Crohn's disease; Surgery; Disease; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006923375,0.0003101904,0.0004099984,0.0001258405,0.00006910139,0.00001852466,0.0004141512,0.0002155475,0.0006825016],"category_scores_gemma":[0.000004050792,0.0003021831,0.0002975287,0.0001212367,0.0003572203,0.00001676434,0.000141786,0.000237089,0.00003037097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003463812,"about_ca_system_score_gemma":0.000314418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002068837,"about_ca_topic_score_gemma":0.000006405732,"domain_scores_codex":[0.9969747,0.0009034114,0.0009624836,0.0005027986,0.0002165624,0.0004400635],"domain_scores_gemma":[0.99871,0.0001404958,0.0003282289,0.0004435148,0.0001070697,0.0002707271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4069018,0.004245369,0.2239486,0.0001226141,0.005873628,0.000495868,0.0001314722,0.0004014675,0.3535837,0.00002233015,0.002564743,0.001708433],"study_design_scores_gemma":[0.4173993,0.0007109264,0.467034,0.00003331781,0.004098602,0.000002200481,0.00003880186,0.00128174,0.1041672,0.0001284577,0.00442067,0.0006847802],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951369,0.0004842856,0.0000444997,0.001020742,0.0009212603,0.002235926,0.00004981408,0.0000245453,0.00008199465],"genre_scores_gemma":[0.9784006,0.0003261041,0.0003740145,0.01979449,0.000394524,0.0003257025,0.0002726186,0.00005233003,0.00005959559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2494165,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376615730857864,"score_gpt":0.3444898807615983,"score_spread":0.3107237234530196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}