{"id":"W2007880640","doi":"10.1016/j.tiv.2013.04.013","title":"Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2","year":2013,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Hydrogen peroxide; Programmed cell death; Apoptosis; Necrosis; Matrix metalloproteinase; Oxidative stress; Reactive oxygen species; Chemistry; Lactate dehydrogenase; Intracellular; Cell biology; Caspase; Cell; Molecular biology; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002768654,0.0002158503,0.0003840199,0.000165815,0.00002661813,0.00000982678,0.0002772639,0.0004119154,0.0001345778],"category_scores_gemma":[0.00004915596,0.0002145602,0.0001382828,0.0001364667,0.00004319871,0.00001090661,0.0001874882,0.0002046065,0.00005438593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005323535,"about_ca_system_score_gemma":0.000116535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708736,"about_ca_topic_score_gemma":0.00004342279,"domain_scores_codex":[0.9984309,0.0001585019,0.0004116636,0.0004296304,0.0001462888,0.0004230079],"domain_scores_gemma":[0.9993063,0.00001475128,0.0001250134,0.0004118487,0.00005451351,0.00008760621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008807846,0.0001796775,0.001061412,0.00002824606,0.00003282892,0.00002112353,0.00005933855,0.00001910666,0.9982098,0.00003048798,0.0000655514,0.000204306],"study_design_scores_gemma":[0.001105575,0.0004299572,0.001404658,0.00001030783,0.00001779869,0.00001605045,0.00007055905,0.00008092878,0.9959118,0.0006180446,0.0001260854,0.0002082032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974774,0.0007242385,0.00005595271,0.0001211975,0.00008730935,0.0008489863,0.00001179922,0.000009651254,0.0006634513],"genre_scores_gemma":[0.9980791,0.00003387294,0.0008903886,0.0002927684,0.00007095957,0.0003162253,0.0000251314,0.00002660194,0.0002649055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002298011,"threshold_uncertainty_score":0.874951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140704120227053,"score_gpt":0.2452664227335759,"score_spread":0.2338593815313054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}