{"id":"W2007908190","doi":"10.1289/ehp.8751","title":"The OECD Program to Validate the Rat Hershberger Bioassay to Screen Compoundsfor <i>in Vivo</i> Androgen and Antiandrogen Responses. Phase 1: Use of a Potent Agonistand a Potent Antagonist to Test the Standardized Protocol","year":2006,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Antiandrogen; In vivo; Androgen receptor; Androgen; Bioassay; Antagonist; Flutamide; Pharmacology; Medicine; Endocrinology; Chemistry; Biology; Internal medicine; Prostate cancer; Hormone; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008093679,0.0002939952,0.0002789378,0.00005508834,0.0007309727,0.0001384143,0.0002559155,0.00009316977,0.000005183278],"category_scores_gemma":[0.00004137318,0.0001633882,0.0001185552,0.000158594,0.0003893892,0.00001138054,0.0002400027,0.0001770346,0.000006119564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893438,"about_ca_system_score_gemma":0.0001153094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003561112,"about_ca_topic_score_gemma":0.0002094324,"domain_scores_codex":[0.9977198,0.0004334026,0.0004266959,0.0005429846,0.0003277787,0.0005492997],"domain_scores_gemma":[0.9989688,0.0001192408,0.0001428076,0.0005032849,0.00002045067,0.0002453683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01692667,0.004562491,0.007877401,0.00007399199,0.0002834449,0.00005773218,0.003765685,0.0004097529,0.9339288,0.0001338746,0.01326785,0.01871233],"study_design_scores_gemma":[0.005969332,0.01154493,0.004833299,0.00009236,0.00005066981,0.0001204481,0.005121478,0.00009017748,0.4555531,0.00002288405,0.5160478,0.0005535259],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938202,0.001531547,0.000148026,0.01082646,0.00004570562,0.04850054,0.0006371062,0.00001937108,0.00008927999],"genre_scores_gemma":[0.9882105,0.0002531103,0.0007143368,0.0007182001,0.00008566815,0.009443052,0.00003240903,0.00004915587,0.0004935953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5027799,"threshold_uncertainty_score":0.6662776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029826553395383,"score_gpt":0.3087208045355343,"score_spread":0.2984225390015804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}