{"id":"W2007908190","doi":"10.1289/ehp.8751","title":"The OECD Program to Validate the Rat Hershberger Bioassay to Screen Compoundsfor <i>in Vivo</i> Androgen and Antiandrogen Responses. Phase 1: Use of a Potent Agonistand a Potent Antagonist to Test the Standardized Protocol","year":2006,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Antiandrogen; In vivo; Androgen receptor; Androgen; Bioassay; Antagonist; Flutamide; Pharmacology; Medicine; Endocrinology; Chemistry; Biology; Internal medicine; Prostate cancer; Hormone; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01347957,0.003201498,0.001146237,0.006260311,0.002265781,0.00156021,0.00335492,0.001715773,0.00670993],"category_scores_gemma":[0.004063446,0.001229832,0.002028648,0.002997465,0.001441837,0.001012068,0.002045731,0.001686891,0.005588147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00257366,"about_ca_system_score_gemma":0.009594085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01393686,"about_ca_topic_score_gemma":0.02268843,"domain_scores_codex":[0.983003,0.007552107,0.001208378,0.0009818948,0.006470589,0.0007839936],"domain_scores_gemma":[0.9859622,0.001038512,0.001545188,0.002857585,0.008009232,0.0005872014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003446031,0.004847072,0.01506978,0.002447771,0.0005564429,0.0005380004,0.0004564518,0.003668305,0.7981654,0.0092926,0.02976365,0.1317486],"study_design_scores_gemma":[0.001007351,0.02831863,0.04303668,0.0009427084,0.0009548081,0.001339773,0.0002857205,0.002253732,0.6202811,0.001154218,0.3001579,0.0002673662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2574186,0.02155926,0.4557044,0.002235383,0.002320456,0.05413652,0.05349545,0.006778691,0.1463512],"genre_scores_gemma":[0.1943764,0.02138942,0.499064,0.002631421,0.0005346923,0.06041477,0.1284402,0.001125714,0.09202352],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01393686,"threshold_uncertainty_score":0.07128757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029826553395383,"score_gpt":0.3087208045355343,"score_spread":0.2984225390015804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}