{"id":"W2007922488","doi":"10.1083/jcb.200110119","title":"Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons","year":2002,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":422,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Intracellular; Biology; Programmed cell death; Extracellular; Cytosol; Cell biology; Cell culture; Cytotoxicity; Apoptosis; Caspase; Molecular biology; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002627326,0.0003546841,0.0004315752,0.0001599039,0.0002199303,0.0003820708,0.000188384,0.0002829978,0.0009209084],"category_scores_gemma":[0.0001951433,0.0001905517,0.0003557417,0.0001518383,0.0002161051,0.0002229251,0.0002319691,0.0004346781,0.0005073163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243557,"about_ca_system_score_gemma":0.0002599809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007527507,"about_ca_topic_score_gemma":0.0009778165,"domain_scores_codex":[0.999671,0.00007488202,0.00004358268,0.00006467263,0.00008902285,0.00005681066],"domain_scores_gemma":[0.999879,0.00004310781,0.00001481071,0.00002478889,0.00002184585,0.00001654992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003787048,0.0000685944,0.000298004,0.0001076396,0.00001917099,0.0002692424,0.00008261496,0.0001299524,0.9965287,0.0001111943,0.00008280986,0.001923491],"study_design_scores_gemma":[0.0000693023,0.0008682186,0.003057721,0.00001409742,0.00004067445,0.0006156412,0.00004908512,0.0008608937,0.9931822,0.00008740702,0.001148946,0.000005696035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901849,0.004961838,0.002030243,0.0001205243,0.00006350188,0.0000402471,0.0003336383,0.00006111624,0.002204045],"genre_scores_gemma":[0.9915706,0.003285083,0.002117393,0.00005119474,0.00001869146,0.00009592334,0.0003990499,0.00001317794,0.002448838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009209084,"threshold_uncertainty_score":0.003080785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784966361883567,"score_gpt":0.291385242476941,"score_spread":0.2635355788581054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}