{"id":"W2007926954","doi":"10.1021/bi0115075","title":"Potent Gene-Specific Inhibitory Properties of Mixed-Backbone Antisense Oligonucleotides Comprised of 2‘-Deoxy-2‘-fluoro-d-arabinose and 2‘-Deoxyribose Nucleotides,","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNase H; Oligonucleotide; Molecular biology; RNA; Phosphodiester bond; DNA; RNase P; Nuclease; Antisense RNA; Ribonuclease; Deoxyribozyme; Messenger RNA; Chemistry; Gene expression; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307633,0.0005182069,0.0002726345,0.0001001099,0.00006756363,0.0001711565,0.0001179879,0.0002064353,0.0006011514],"category_scores_gemma":[0.0001285355,0.00009742502,0.0001820138,0.00009165765,0.0001725069,0.00013704,0.00007773519,0.0003430286,0.0001881625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778219,"about_ca_system_score_gemma":0.0001707234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004687213,"about_ca_topic_score_gemma":0.0008548297,"domain_scores_codex":[0.9999065,0.00001443323,0.000007967277,0.00002806435,0.00002470141,0.00001825653],"domain_scores_gemma":[0.9998925,0.00003696946,0.00002365869,0.000006802639,0.00001782486,0.00002227625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002349137,0.000008185327,0.00003301028,0.00001668563,0.000002092138,0.000006768689,0.000004454234,0.00003379226,0.999384,0.00002062491,0.000006549679,0.0004602509],"study_design_scores_gemma":[0.00000257868,0.0002683869,0.000521221,0.000001516567,0.000008172364,0.00004148571,0.000003728686,0.0002293902,0.9984447,0.00000750341,0.0004696997,0.000001469638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913906,0.002807714,0.003945378,0.00003300894,0.00003246559,0.00003084675,0.0002072009,0.0000517576,0.001500942],"genre_scores_gemma":[0.992609,0.00129658,0.003978715,0.00004479272,0.00001532264,0.00003262767,0.0004087218,0.00001837084,0.001595945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006011514,"threshold_uncertainty_score":0.002011001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319955896047124,"score_gpt":0.1863994848323046,"score_spread":0.1731999258718334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}