{"id":"W2007926954","doi":"10.1021/bi0115075","title":"Potent Gene-Specific Inhibitory Properties of Mixed-Backbone Antisense Oligonucleotides Comprised of 2‘-Deoxy-2‘-fluoro-<scp>d</scp>-arabinose and 2‘-Deoxyribose Nucleotides<sup>,</sup>","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNase H; Oligonucleotide; Molecular biology; RNA; Phosphodiester bond; DNA; RNase P; Nuclease; Antisense RNA; Ribonuclease; Deoxyribozyme; Messenger RNA; Chemistry; Gene expression; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002187466,0.0005897507,0.0006750896,0.00007640004,0.0001383846,0.00004214377,0.0005060304,0.0005656514,0.00004068305],"category_scores_gemma":[0.0002396646,0.0005887304,0.0003087241,0.0001971496,0.001025186,0.00001836315,0.0004146939,0.0002729662,0.00001657863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003755039,"about_ca_system_score_gemma":0.00006840329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001212293,"about_ca_topic_score_gemma":4.445979e-7,"domain_scores_codex":[0.9970584,0.00006804051,0.0008997187,0.00092517,0.0004382291,0.0006104708],"domain_scores_gemma":[0.9977663,0.0000429459,0.0004571797,0.001098578,0.0003043367,0.0003306184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007665661,0.0004618769,0.00174958,0.0006015379,0.0001631716,0.00002255364,0.0002402284,0.00004467154,0.9836943,0.000006419707,0.01156877,0.001370299],"study_design_scores_gemma":[0.001392942,0.0001718455,0.0007145132,0.0002242242,0.00006998544,0.0001266188,0.0007734829,0.0002721889,0.9917024,0.00001214021,0.004198525,0.000341068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821115,0.01557257,0.00002186275,0.00005319845,0.000105969,0.0002614333,0.0001379755,0.00005590268,0.00167956],"genre_scores_gemma":[0.994145,0.002723792,0.001032518,0.00006074512,0.0003787189,0.00001858338,0.0001035023,0.00009854467,0.001438598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01284878,"threshold_uncertainty_score":0.9996564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319955896047124,"score_gpt":0.1863994848323046,"score_spread":0.1731999258718334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}