{"id":"W2007944863","doi":"10.1523/jneurosci.5025-12.2014","title":"Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Wakefulness; SIRT3; Neuroscience; Chemistry; Oxidative stress; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Sirtuin; NAD+ kinase; Electroencephalography; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009713605,0.0002613079,0.0002419859,0.0003415624,0.0001929111,0.000210877,0.0001907766,0.0003093091,0.0007544829],"category_scores_gemma":[0.0001332838,0.0001458463,0.0002468546,0.0001027458,0.000460519,0.0003085698,0.0004568475,0.0006415656,0.0001550952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185026,"about_ca_system_score_gemma":0.0002254462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005682324,"about_ca_topic_score_gemma":0.001386674,"domain_scores_codex":[0.99992,0.0000056585,0.000009472284,0.00002875959,0.00001850634,0.00001762015],"domain_scores_gemma":[0.9998997,0.000004946858,0.00003799322,0.00001514323,0.000008873936,0.00003327801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003743718,0.00004139273,0.004901682,0.00005670944,0.00003245051,0.0009539198,0.0000876132,0.00007228257,0.9857497,0.0001976734,0.0001027586,0.007429327],"study_design_scores_gemma":[0.0001031498,0.001210995,0.4722667,0.00006388388,0.0001220485,0.01299574,0.0004450257,0.001045872,0.5056062,0.002152504,0.003952128,0.00003582672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99638,0.001381873,0.00140446,0.0001305531,0.00002560121,0.000007184005,0.0001009871,0.00006443697,0.0005049658],"genre_scores_gemma":[0.9973555,0.0005007627,0.0007496029,0.00009454754,0.000007403467,0.00001695222,0.000113411,0.00001783299,0.001143969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007544829,"threshold_uncertainty_score":0.002523959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04773304644079188,"score_gpt":0.3039351333795147,"score_spread":0.2562020869387228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}