{"id":"W2007949372","doi":"10.1093/humrep/dev079","title":"Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges","year":2015,"lang":"en","type":"letter","venue":"Human Reproduction","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Genetics; Biology; Medicine; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004928621,0.0004650803,0.000696214,0.0003573516,0.000324788,0.0000944031,0.0001323537,0.0006238004,0.00001566872],"category_scores_gemma":[0.0008934928,0.0004800486,0.00010071,0.0001695489,0.0002035784,0.0002429395,0.0001722638,0.001424526,0.000007961396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001259444,"about_ca_system_score_gemma":0.00009205627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645263,"about_ca_topic_score_gemma":0.000008031604,"domain_scores_codex":[0.9965259,0.0002335385,0.0005510143,0.001424353,0.0007947129,0.0004705078],"domain_scores_gemma":[0.9975808,0.0002413153,0.0004981188,0.0009770041,0.0005369275,0.0001658944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001295328,0.0002755646,0.01224678,0.01337854,0.001908375,0.008091873,0.007423659,0.004964941,0.02234812,0.0001000182,0.6415055,0.2864613],"study_design_scores_gemma":[0.008692862,0.006402145,0.2697354,0.05914129,0.00814474,0.05060923,0.00297259,0.01046077,0.00483754,0.002163624,0.5707302,0.006109594],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5882594,0.1607531,0.01007936,0.231916,0.002051553,0.004133482,0.00006846234,0.001487802,0.001250797],"genre_scores_gemma":[0.6254967,0.01306819,0.1645538,0.09437195,0.09386378,0.000247649,0.003900968,0.0009898338,0.003507144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2803517,"threshold_uncertainty_score":0.9997651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2873193349241969,"score_gpt":0.3639550063693455,"score_spread":0.0766356714451486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}