{"id":"W2007962601","doi":"10.1073/pnas.0812374106","title":"Ca <sup>2+</sup> binding by domain 2 plays a critical role in the activation and stabilization of gelsolin","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biomedical Research Council; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; University of British Columbia; National Science Council; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada; Howard Hughes Medical Institute","keywords":"Gelsolin; Binding site; Cleavage (geology); Actin; Biophysics; Binding domain; Plasma protein binding; Chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009697946,0.0002574719,0.0001696735,0.00008715317,0.0002683951,0.0002734971,0.0002559335,0.0003732505,0.001489372],"category_scores_gemma":[0.0001208939,0.0001354293,0.0002440289,0.00009468438,0.0002727183,0.000228523,0.00023612,0.0003779632,0.0006273082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002099165,"about_ca_system_score_gemma":0.0001659808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006312825,"about_ca_topic_score_gemma":0.0006725932,"domain_scores_codex":[0.9999332,0.000009392045,0.00000435028,0.0000171809,0.00001543597,0.00002053228],"domain_scores_gemma":[0.999933,0.00001054857,0.00002062797,0.000007710506,0.000008807833,0.0000192389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003014025,0.00001868432,0.001233167,0.00005834011,0.000006766278,0.0002464796,0.00003265585,0.0001852566,0.9960836,0.00029468,0.0001544887,0.001384489],"study_design_scores_gemma":[0.00006446785,0.0002644379,0.04777588,0.00002585753,0.0000200788,0.001762011,0.0001094305,0.003634519,0.9357592,0.0006079146,0.009956094,0.00002005691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930069,0.001298343,0.003242483,0.0001227311,0.00002232799,0.00001632297,0.0001797625,0.00008352072,0.002027565],"genre_scores_gemma":[0.9957954,0.0002088582,0.002301993,0.00006590447,0.00001000237,0.00001135685,0.0003200042,0.00001764623,0.001268903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489372,"threshold_uncertainty_score":0.004982471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706679953149579,"score_gpt":0.3020571819881751,"score_spread":0.2849903824566793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}