{"id":"W2007962601","doi":"10.1073/pnas.0812374106","title":"Ca <sup>2+</sup> binding by domain 2 plays a critical role in the activation and stabilization of gelsolin","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biomedical Research Council; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; University of British Columbia; National Science Council; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada; Howard Hughes Medical Institute","keywords":"Gelsolin; Binding site; Cleavage (geology); Actin; Biophysics; Binding domain; Plasma protein binding; Chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007012,0.00007332326,0.00009789321,0.00007585838,0.00009024694,0.00001459476,0.0002922176,0.00008501777,0.000002652982],"category_scores_gemma":[0.0007201305,0.00004620657,0.00003431112,0.0002985031,0.000364508,0.00003848487,0.00004581466,0.00006354271,1.183672e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001690022,"about_ca_system_score_gemma":0.00001997551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006580096,"about_ca_topic_score_gemma":1.216946e-7,"domain_scores_codex":[0.9990467,0.00001457181,0.0002199122,0.0001796865,0.0004338418,0.0001052155],"domain_scores_gemma":[0.999608,0.0001036012,0.0001642128,0.00001019233,0.00009777564,0.00001625327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002262429,0.0001161975,0.02699543,0.00002120602,0.000008010085,2.571845e-9,0.0006044985,0.0001678379,0.9620613,0.009354694,0.0004384063,0.0002097311],"study_design_scores_gemma":[0.0002691486,0.0001570538,0.04575014,0.00004897541,0.00000997944,0.000002995299,0.001738715,0.0006743936,0.9389615,0.01222113,0.00009893513,0.00006705274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940863,0.0001611473,0.000005957698,0.005073953,0.000002240467,0.0001519489,0.00001668515,0.000001633215,0.0005001446],"genre_scores_gemma":[0.9990665,0.00007148407,0.0004731328,0.0003449908,0.00002305787,0.000008873641,0.000001718825,0.000002200279,0.000008025828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02309988,"threshold_uncertainty_score":0.1884249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706679953149579,"score_gpt":0.3020571819881751,"score_spread":0.2849903824566793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}