{"id":"W2007973078","doi":"10.1080/15459620590916198","title":"Evaluation of Potential Toxicity from Co-Exposure to Three CNS Depressants (Toluene, Ethylbenzene, and Xylene) Under Resting and Working Conditions Using PBPK Modeling","year":2005,"lang":"en","type":"article","venue":"Journal of Occupational and Environmental Hygiene","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Work & Health; Workplace Health, Safety and Compensation Commission","funders":"Agency for Toxic Substances and Disease Registry; National Institute of Environmental Health Sciences","keywords":"Physiologically based pharmacokinetic modelling; Ethylbenzene; Threshold limit value; Occupational exposure limit; Toluene; Chemistry; Occupational exposure; Toxicokinetics; Pharmacokinetics; Toxicology; Xylene; Inhalation exposure; Environmental chemistry; Toxicity; Pharmacology; Environmental health; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000373349,0.0001025509,0.0001353251,0.00005729258,0.0001284995,0.00002128589,0.00004489656,0.00007353912,0.00001918279],"category_scores_gemma":[0.0000207212,0.00009938265,0.00004024842,0.0000252745,0.00005217301,0.00002115574,0.0000784074,0.00006835641,1.436979e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004692269,"about_ca_system_score_gemma":0.00004579987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003623277,"about_ca_topic_score_gemma":0.00008291545,"domain_scores_codex":[0.9989927,0.00005281245,0.0002952209,0.000170864,0.0003863745,0.0001020344],"domain_scores_gemma":[0.9996015,0.00001636674,0.0001653921,0.0000741711,0.00005153779,0.00009103465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001030313,0.00005680829,0.03847076,0.000002889455,0.00006214884,7.873259e-7,0.00005026779,0.2238158,0.7323364,0.000003554574,0.000004177122,0.005093349],"study_design_scores_gemma":[0.001469637,0.000276549,0.7596205,0.00006898743,0.0002384251,0.0001030835,0.0003794747,0.1297076,0.1075821,0.0003478343,0.00001809982,0.0001877037],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847914,0.00158462,0.01332309,0.00005308186,0.00003392637,0.00009830294,0.0001031192,8.946339e-7,0.00001158956],"genre_scores_gemma":[0.9944946,0.0001729731,0.004994155,0.00008130259,0.000191443,0.000001846501,0.00005359808,0.000008165202,0.000001922962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7211498,"threshold_uncertainty_score":0.4052707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05526296185822826,"score_gpt":0.3206249218360095,"score_spread":0.2653619599777812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}