{"id":"W2008047439","doi":"10.1016/j.tetlet.2010.03.066","title":"Expedient synthesis of novel bicyclic peptidomimetic scaffolds","year":2010,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Info-communications Media Development Authority; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Peptidomimetic; Bicyclic molecule; Combinatorial chemistry; Stereochemistry; Peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786299,0.0005139812,0.0004745534,0.0003175563,0.00026722,0.0003933939,0.0005311184,0.0003781554,0.002663128],"category_scores_gemma":[0.00023385,0.0002021119,0.0001645387,0.0003478719,0.000188441,0.0003653977,0.0005431411,0.0007927468,0.0009475496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000431496,"about_ca_system_score_gemma":0.0004789844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003477861,"about_ca_topic_score_gemma":0.0012371,"domain_scores_codex":[0.9998279,0.00002500005,0.00001297342,0.00002946783,0.00004582764,0.00005883393],"domain_scores_gemma":[0.9999204,0.00001408683,0.00001722494,0.000008854844,0.00001173005,0.00002766921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005725403,0.0001794109,0.0002182845,0.0004350231,0.00003081798,0.0006426043,0.0001729709,0.002675869,0.9439293,0.006181636,0.00113424,0.04382732],"study_design_scores_gemma":[0.0003034792,0.001805265,0.0009985144,0.00003852688,0.00004490326,0.0006912536,0.00005479398,0.004196259,0.9546359,0.001247923,0.03593174,0.00005142869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8697176,0.006474277,0.07981791,0.0006770295,0.0003928977,0.000789327,0.00222854,0.0008522155,0.0390502],"genre_scores_gemma":[0.925693,0.003120548,0.05791754,0.0002386288,0.00005039874,0.0002711451,0.001409056,0.00007169981,0.01122791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002663128,"threshold_uncertainty_score":0.008909047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006227046628654927,"score_gpt":0.2255823413295172,"score_spread":0.2193552947008623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}