{"id":"W2008047439","doi":"10.1016/j.tetlet.2010.03.066","title":"Expedient synthesis of novel bicyclic peptidomimetic scaffolds","year":2010,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Info-communications Media Development Authority; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Peptidomimetic; Bicyclic molecule; Combinatorial chemistry; Stereochemistry; Peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507909,0.0001638198,0.000227578,0.00006889467,0.0000399499,0.00001318137,0.0002665296,0.0001280296,0.0001527406],"category_scores_gemma":[0.000166348,0.0001455863,0.0002557976,0.0001185154,0.0001638611,0.000003073804,0.00007206581,0.00007389691,0.00001251783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008502556,"about_ca_system_score_gemma":0.00001373047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005408307,"about_ca_topic_score_gemma":0.00002404316,"domain_scores_codex":[0.9989637,0.00001669551,0.0002624532,0.0003348503,0.0001742897,0.0002480526],"domain_scores_gemma":[0.9992613,0.00005105635,0.0001059744,0.0004539338,0.00002889968,0.0000988393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001754621,0.0001345445,0.001652569,0.00001391064,0.00008251771,7.837744e-7,0.00001211828,0.0000097167,0.993588,0.00002200177,0.001582857,0.002883406],"study_design_scores_gemma":[0.0002389747,0.00002637975,0.001674924,0.00001232958,0.0000743596,0.000005653835,0.00002250294,0.00006212688,0.991593,0.000003107916,0.006098648,0.0001880105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975424,0.00005199503,0.0004853849,0.0007555851,0.0001107682,0.00006618716,0.00001413326,0.00001315555,0.0009603381],"genre_scores_gemma":[0.997179,0.00002112924,0.001911936,0.0004333816,0.0002826542,0.00002037166,0.00001504524,0.0000238511,0.000112592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004515791,"threshold_uncertainty_score":0.5936837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006227046628654927,"score_gpt":0.2255823413295172,"score_spread":0.2193552947008623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}