{"id":"W2008062395","doi":"10.1007/s00401-007-0230-9","title":"Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation","year":2007,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"LRRK2; Inflammation; Degeneration (medical); Pathology; Mutation; Biology; Medicine; Genetics; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290536,0.001084773,0.0004821203,0.0008519186,0.0005619697,0.000333645,0.0004440304,0.00125957,0.00310645],"category_scores_gemma":[0.0007010922,0.0003205332,0.0003650685,0.0006066294,0.0009854743,0.0004642898,0.0004657386,0.0007843326,0.000389803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261571,"about_ca_system_score_gemma":0.0002783596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007277362,"about_ca_topic_score_gemma":0.0009925469,"domain_scores_codex":[0.9997426,0.00006605133,0.00004550062,0.00006560273,0.00004220623,0.00003803358],"domain_scores_gemma":[0.9994777,0.0000940165,0.0002979441,0.00002840077,0.00002735966,0.00007452958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01327949,0.00100947,0.1623895,0.0006946165,0.0006429948,0.3646888,0.001307209,0.000439346,0.4357145,0.00241186,0.001229643,0.01619263],"study_design_scores_gemma":[0.000853961,0.002139855,0.4651125,0.0001270731,0.0008310977,0.477917,0.0006450771,0.002373424,0.04182857,0.003656061,0.004440522,0.00007483079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969404,0.0009687205,0.000654582,0.0002180421,0.00002158771,0.00001380694,0.0001064251,0.00003220414,0.001044301],"genre_scores_gemma":[0.9983622,0.0003087387,0.0004400225,0.0000573064,0.00004648942,0.00001127479,0.000104873,0.00000845788,0.0006606365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00310645,"threshold_uncertainty_score":0.01039207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012885770862173,"score_gpt":0.2669048185368819,"score_spread":0.2467759608282601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}