{"id":"W2008077991","doi":"10.1038/sj.clpt.6100191","title":"Induction of Intestinal P-glycoprotein by St John's Wort Reduces the Oral Bioavailability of Talinolol","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; Australian Geographic Society","keywords":"Bioavailability; Pharmacokinetics; Cmax; Pharmacology; P-glycoprotein; CYP3A4; Oral administration; Ex vivo; Chemistry; Medicine; Internal medicine; Cytochrome P450; Metabolism; In vitro; Biochemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720862,0.0002632288,0.0004990625,0.0001201956,0.00009481431,0.0002503963,0.0001541823,0.0002259597,0.001056576],"category_scores_gemma":[0.0003423427,0.0001283914,0.0002683101,0.0001080094,0.0002901384,0.0001727873,0.0001126316,0.0004825412,0.0001547448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706486,"about_ca_system_score_gemma":0.0001739565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004440156,"about_ca_topic_score_gemma":0.0006734398,"domain_scores_codex":[0.9998603,0.00005209485,0.00001104373,0.00002315503,0.00002320163,0.00003016646],"domain_scores_gemma":[0.9997907,0.00004578375,0.00007460301,0.00001816865,0.00001171681,0.00005899299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03129609,0.0022153,0.002180904,0.0002266028,0.0001050704,0.0001574546,0.00007489454,0.000104491,0.9407124,0.00007151703,0.0002233587,0.02263204],"study_design_scores_gemma":[0.00691544,0.2494384,0.1142454,0.00004000604,0.000472002,0.001011438,0.0002346096,0.003514758,0.6206027,0.000129895,0.003360433,0.00003490833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994015,0.0003361748,0.00009541438,0.00003315994,0.00000971222,0.000008500145,0.00001854176,0.00001160847,0.00008531188],"genre_scores_gemma":[0.9988726,0.000319584,0.0002181788,0.00003683006,0.0000186289,0.00001399288,0.00006658686,0.000005139212,0.0004485195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056576,"threshold_uncertainty_score":0.003534615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08313587851896263,"score_gpt":0.4164257863340057,"score_spread":0.3332899078150431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}