{"id":"W2008087194","doi":"10.1016/j.bmc.2014.02.011","title":"[Dmt1]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Nanjing Medical University","keywords":"Chemistry; Agonist; Stereochemistry; Potency; Peptide; Opioid; Isopropyl; Receptor; Opioid receptor; Pharmacology; Biochemistry; In vitro; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002238806,0.0003459146,0.0003313673,0.00001691473,0.0001530028,0.000030209,0.0002262831,0.0002434101,0.00017865],"category_scores_gemma":[0.0001212146,0.0002351609,0.00004650528,0.0001379786,0.0002726755,0.000008480034,0.0001118484,0.0002505219,0.000008219884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003103887,"about_ca_system_score_gemma":0.000163526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003172873,"about_ca_topic_score_gemma":0.00001443171,"domain_scores_codex":[0.9983975,0.00005512681,0.0001618719,0.0006652777,0.000282414,0.0004378389],"domain_scores_gemma":[0.9990824,0.00003366125,0.0001355424,0.0003223338,0.00009536112,0.0003306465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004858901,0.0001023065,0.0001765413,0.0001754434,0.00006952895,0.00001002359,0.00003512618,4.885831e-7,0.9913359,0.000007207432,0.0004808107,0.007120733],"study_design_scores_gemma":[0.001441122,0.00134853,0.001841917,0.00008198079,0.00008444647,0.00008864227,0.00009894788,0.00004091072,0.9902589,0.00002872479,0.004328185,0.0003577175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929626,0.0003716544,0.004174066,0.0001515255,0.00008967451,0.0002466568,0.00001934893,0.0000463112,0.00193818],"genre_scores_gemma":[0.9974734,0.0001700509,0.0007402107,0.000264244,0.0004881925,0.00005573816,0.0001341296,0.00003666697,0.0006373613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006763015,"threshold_uncertainty_score":0.9589582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005123640343020703,"score_gpt":0.2180157613644668,"score_spread":0.2128921210214461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}