{"id":"W2008091234","doi":"10.1073/pnas.1005267107","title":"Prion disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; University of British Columbia Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; University of Saskatchewan; Canadian Light Source","keywords":"Circular dichroism; Histone octamer; Prion protein; Chemistry; Sedimentation equilibrium; Monomer; Protein folding; Biophysics; Native state; Protein structure; Biology; Biochemistry; Disease; Ultracentrifuge; DNA; Nucleosome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025477,0.000198561,0.0001859183,0.0005352461,0.000113116,0.0002769022,0.00007593502,0.0002166967,0.0007137386],"category_scores_gemma":[0.0004429253,0.0001429727,0.0001151888,0.0002209354,0.0002283277,0.0001891717,0.0001618153,0.0002103954,0.0002699964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007750816,"about_ca_system_score_gemma":0.00004455283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000140645,"about_ca_topic_score_gemma":0.0001426062,"domain_scores_codex":[0.9998814,0.00003138223,0.00001771688,0.00003059328,0.00002520955,0.00001371722],"domain_scores_gemma":[0.9995315,0.00009737066,0.0001957846,0.00003238597,0.00004553563,0.00009746124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001993192,0.0000433911,0.01986648,0.0000252762,0.00003115633,0.0001305608,0.00006336608,0.00005774524,0.9777582,0.00005011886,0.00002350144,0.001750978],"study_design_scores_gemma":[0.00002335893,0.0009941484,0.6924029,0.00001421978,0.00008056669,0.003306764,0.0001412733,0.00139487,0.3004374,0.0003901082,0.000794031,0.00002026678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992068,0.0002517605,0.0002522481,0.000009147334,0.000001483158,0.000002486746,0.00002645423,0.000008621321,0.0002410109],"genre_scores_gemma":[0.9995313,0.0001017206,0.0001615125,0.0000119452,0.000002132636,0.000002732025,0.0000556741,0.000002237555,0.0001306704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007137386,"threshold_uncertainty_score":0.002387702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629651923764923,"score_gpt":0.2901548648788402,"score_spread":0.2738583456411909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}