{"id":"W2008091234","doi":"10.1073/pnas.1005267107","title":"Prion disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; University of British Columbia Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; University of Saskatchewan; Canadian Light Source","keywords":"Circular dichroism; Histone octamer; Prion protein; Chemistry; Sedimentation equilibrium; Monomer; Protein folding; Biophysics; Native state; Protein structure; Biology; Biochemistry; Disease; Ultracentrifuge; DNA; Nucleosome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004644796,0.00007713157,0.00008515736,0.00004961745,0.0001189483,0.00001989294,0.0002591021,0.00006118215,0.00001258025],"category_scores_gemma":[0.0005838402,0.00005525544,0.00004266619,0.0002000026,0.000479003,0.00003317881,0.0001742333,0.0001619518,9.635087e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001046451,"about_ca_system_score_gemma":0.00003600823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001301853,"about_ca_topic_score_gemma":0.000003753575,"domain_scores_codex":[0.9991554,0.000008929749,0.0001681209,0.0002658416,0.0002963635,0.0001053291],"domain_scores_gemma":[0.9996309,0.00001849352,0.0001644026,0.00001270369,0.0001169854,0.00005647798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003641138,0.00003044508,0.04603535,0.00003942051,0.000004581607,4.094346e-9,0.00003212212,0.000008892534,0.9505192,0.0004059492,0.0002183521,0.00266925],"study_design_scores_gemma":[0.0001554497,0.00002583336,0.2676354,0.00004223731,0.000007014343,0.000002853024,0.00004667554,0.0006719341,0.7248101,0.006154606,0.0003713307,0.00007661126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981305,0.0003010122,0.000005605898,0.001203531,0.00001640097,0.0002240848,0.00004350041,0.000003102317,0.00007224378],"genre_scores_gemma":[0.9992859,0.00005104289,0.0004212438,0.0001722277,0.00003840659,0.000005849485,0.000001056386,0.000002878652,0.00002140066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2257092,"threshold_uncertainty_score":0.2253251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629651923764923,"score_gpt":0.2901548648788402,"score_spread":0.2738583456411909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}