{"id":"W2008092626","doi":"10.1016/j.brainres.2009.09.105","title":"Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)","year":2009,"lang":"en","type":"article","venue":"Brain Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Messenger RNA; RNA-binding protein; Motor neuron; Amyotrophic lateral sclerosis; Biology; Molecular biology; Neurodegeneration; Cell biology; Neurofilament; Three prime untranslated region; Superoxide dismutase; Chemistry; Untranslated region; Biochemistry; Internal medicine; Neuroscience; Oxidative stress; Gene; Immunology; Spinal cord; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001953846,0.000229258,0.0003170851,0.0004105399,0.0002917703,0.000161545,0.0004546847,0.000153025,0.000009979339],"category_scores_gemma":[0.001497007,0.0002145784,0.00009260435,0.0005723426,0.0001940218,0.00004341505,0.0002902024,0.0003726386,0.000003294405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260366,"about_ca_system_score_gemma":0.0002761922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000291567,"about_ca_topic_score_gemma":0.0003205387,"domain_scores_codex":[0.9969973,0.0003403051,0.0005139604,0.0007802942,0.0004064869,0.0009616431],"domain_scores_gemma":[0.9984827,0.00008786152,0.00007842811,0.0005706372,0.0004324505,0.000347915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000634117,0.0002035628,0.002213774,0.0001734353,0.00001565045,0.000002756963,0.000213024,0.00002180287,0.9828612,0.00005448033,0.0003579612,0.01324826],"study_design_scores_gemma":[0.001488084,0.001699399,0.03503883,0.0004517584,0.000003735661,0.000005763447,0.0001537251,0.000939005,0.9589193,0.000491115,0.0005112763,0.0002980182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986963,0.000196245,0.0002942252,0.00915406,0.00001136403,0.003161413,0.0001595844,0.00001461263,0.00004547197],"genre_scores_gemma":[0.9967752,0.00004660138,0.00178825,0.0001626229,0.00007912147,0.0006518522,0.0001191264,0.00003960327,0.000337662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03282505,"threshold_uncertainty_score":0.8750255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06788580939063117,"score_gpt":0.3644498832051399,"score_spread":0.2965640738145087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}