{"id":"W2008092626","doi":"10.1016/j.brainres.2009.09.105","title":"Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)","year":2009,"lang":"en","type":"article","venue":"Brain Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Messenger RNA; RNA-binding protein; Motor neuron; Amyotrophic lateral sclerosis; Biology; Molecular biology; Neurodegeneration; Cell biology; Neurofilament; Three prime untranslated region; Superoxide dismutase; Chemistry; Untranslated region; Biochemistry; Internal medicine; Neuroscience; Oxidative stress; Gene; Immunology; Spinal cord; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134504,0.0002068853,0.0001382344,0.0001960547,0.0003609271,0.0004645765,0.0001922187,0.0003396945,0.001718978],"category_scores_gemma":[0.0002838601,0.0001791185,0.0002022104,0.0001002906,0.0003097845,0.0002720104,0.0002953857,0.0004227595,0.0005831979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003652256,"about_ca_system_score_gemma":0.0001966222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004716183,"about_ca_topic_score_gemma":0.0007345305,"domain_scores_codex":[0.9998821,0.00002137208,0.000006827025,0.00003138554,0.00002799905,0.00003030091],"domain_scores_gemma":[0.9998257,0.00002852515,0.00005532793,0.00001512352,0.0000220761,0.0000533404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001646586,0.00002815034,0.0007237805,0.00001717034,0.000007330993,0.0001061836,0.00002666255,0.00005216214,0.9960321,0.0003564741,0.0001313442,0.002353989],"study_design_scores_gemma":[0.00005499658,0.0003713031,0.04134061,0.00001224154,0.00004447095,0.001569672,0.0001350934,0.002849577,0.9453298,0.002169223,0.00611021,0.00001274238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991556,0.002404825,0.003517049,0.0002734707,0.00005072782,0.00001029655,0.0001519402,0.0001372413,0.001898278],"genre_scores_gemma":[0.9960315,0.0003834281,0.001397488,0.000061274,0.000008618891,0.00001057328,0.0002119831,0.00002464025,0.001870485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718978,"threshold_uncertainty_score":0.005750537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06788580939063117,"score_gpt":0.3644498832051399,"score_spread":0.2965640738145087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}