{"id":"W2008151377","doi":"10.1016/j.ccr.2012.02.013","title":"TLX Homeodomain Oncogenes Mediate T Cell Maturation Arrest in T-ALL via Interaction with ETS1 and Suppression of TCRα Gene Expression","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Australian Research Council; Institut National Du Cancer; Centre National de la Recherche Scientifique; Fondation de France; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Terry Fox Foundation; Ministère de l'Enseignement Supérieur et de la Recherche; European Commission; Association pour la Recherche sur le Cancer","keywords":"T-cell receptor; Psychological repression; ETS1; Cancer research; Jurkat cells; T cell; Homeobox; Biology; Gene rearrangement; Gene; Cell biology; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704699,0.0002327372,0.0001346927,0.0002023651,0.0002302565,0.0004192367,0.0002180834,0.000181132,0.002036284],"category_scores_gemma":[0.0001203469,0.0001611596,0.0002172625,0.0001101584,0.0002261524,0.0002515429,0.0003154682,0.0006585069,0.0005876396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473067,"about_ca_system_score_gemma":0.0001437979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004240711,"about_ca_topic_score_gemma":0.000717924,"domain_scores_codex":[0.9998316,0.000031896,0.00001136333,0.00002138099,0.00003333202,0.00007048391],"domain_scores_gemma":[0.9999081,0.00001974068,0.00002408765,0.00001427098,0.000007734109,0.00002610182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185064,0.00002163207,0.0002644393,0.00001089952,0.000003506688,0.0000654695,0.00001558354,0.0000346575,0.9984546,0.0002522013,0.00004820513,0.0007102608],"study_design_scores_gemma":[0.00002747453,0.00009571994,0.006231794,0.000002018793,0.000008436317,0.0004320235,0.00004994877,0.0004828852,0.9902873,0.00007322183,0.002307413,0.0000017709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954453,0.0008689819,0.001640192,0.00009070228,0.00001329983,0.00001529756,0.0001334229,0.00007230989,0.001720583],"genre_scores_gemma":[0.996727,0.0002117002,0.0004216303,0.00002659392,0.000005256091,0.0000114338,0.0002552292,0.000013189,0.002327881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036284,"threshold_uncertainty_score":0.006812036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991268610931361,"score_gpt":0.3018566262188901,"score_spread":0.2819439401095765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}