{"id":"W2008151377","doi":"10.1016/j.ccr.2012.02.013","title":"TLX Homeodomain Oncogenes Mediate T Cell Maturation Arrest in T-ALL via Interaction with ETS1 and Suppression of TCRα Gene Expression","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Australian Research Council; Institut National Du Cancer; Centre National de la Recherche Scientifique; Fondation de France; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Terry Fox Foundation; Ministère de l'Enseignement Supérieur et de la Recherche; European Commission; Association pour la Recherche sur le Cancer","keywords":"T-cell receptor; Psychological repression; ETS1; Cancer research; Jurkat cells; T cell; Homeobox; Biology; Gene rearrangement; Gene; Cell biology; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204549,0.0001727065,0.0002809533,0.0001211771,0.00003220008,0.00001072573,0.00007481657,0.000143337,0.0001885593],"category_scores_gemma":[0.00001940416,0.0001235637,0.00002874568,0.0001458747,0.00007497791,0.000337472,0.00007418749,0.0002044679,0.0000109557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005857416,"about_ca_system_score_gemma":0.000184468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983895,"about_ca_topic_score_gemma":0.000106996,"domain_scores_codex":[0.9986613,0.00008739462,0.0002770995,0.000253159,0.0003783496,0.0003427264],"domain_scores_gemma":[0.9991618,0.0001312368,0.0001662751,0.0002387684,0.00008306016,0.0002188101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001687777,0.0001937619,0.01533008,0.000389544,0.00001164744,0.00002218737,0.001368855,0.00005340342,0.9779798,7.192423e-7,0.0009153469,0.002046821],"study_design_scores_gemma":[0.003544227,0.0002063476,0.01370276,0.0003704728,0.00005467511,0.00002882872,0.0004076521,0.001212147,0.978862,0.00000650207,0.001461986,0.0001423701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938895,0.00315986,0.0009406775,0.0001264334,0.0003834314,0.0004135442,0.00001351793,0.00001970516,0.001053377],"genre_scores_gemma":[0.9961398,0.001245079,0.001747465,0.00008328161,0.0003270535,0.00006341856,0.00006682017,0.00003567485,0.000291464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002250289,"threshold_uncertainty_score":0.5038781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991268610931361,"score_gpt":0.3018566262188901,"score_spread":0.2819439401095765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}