{"id":"W2008185190","doi":"10.1534/genetics.105.045799","title":"Genome-Wide Synthetic Lethal Screens Identify an Interaction Between the Nuclear Envelope Protein, Apq12p, and the Kinetochore in <i>Saccharomyces cerevisiae</i>","year":2005,"lang":"en","type":"article","venue":"Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Biology; Genetics; Saccharomyces cerevisiae; Kinetochore; Chromosome segregation; Genetic screen; Mitosis; Centromere; Gene; Cytokinesis; Chromosome; Anaphase; Synthetic lethality; Genome; Mutant; Cell biology; Cell division; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961884,0.0008254105,0.0003099958,0.0006533036,0.0002781216,0.0004513429,0.0004837488,0.000604814,0.001290046],"category_scores_gemma":[0.0002286244,0.0003089819,0.000363652,0.0003225465,0.0004252173,0.0001252704,0.0005844014,0.0006795255,0.0003893661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004820309,"about_ca_system_score_gemma":0.0002523334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112863,"about_ca_topic_score_gemma":0.0027252,"domain_scores_codex":[0.9997265,0.00003298754,0.00002566726,0.00006793824,0.0001134281,0.00003348973],"domain_scores_gemma":[0.9996783,0.0001004234,0.0001067284,0.0000248051,0.00001896678,0.00007085319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005018381,0.00002611461,0.0003083747,0.00001846652,0.00001391232,0.0002187522,0.00001127622,0.0001234921,0.9982614,0.00008769205,0.00003725061,0.0008430922],"study_design_scores_gemma":[0.00002762709,0.0002385244,0.01000482,0.000007193204,0.00007297215,0.00141456,0.00004816518,0.002197055,0.9838338,0.00009285667,0.002051345,0.00001105027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987799,0.0007152832,0.008529321,0.0001271376,0.00002560576,0.0000681204,0.00105729,0.0003254817,0.001352691],"genre_scores_gemma":[0.9904335,0.0004540863,0.00474515,0.0001172055,0.000009293825,0.00005954419,0.001349629,0.0001014066,0.002730128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290046,"threshold_uncertainty_score":0.004315674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156333315155467,"score_gpt":0.2785458394512649,"score_spread":0.2629125079357182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}