{"id":"W2008210460","doi":"10.1158/1538-7445.am10-1773","title":"Abstract 1773: The addition of Reolysin, an oncolytic reovirus, to irinotecan shows synergistic anticancer activity in colorectal cancer cell lines","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Irinotecan; Colorectal cancer; Oncolytic virus; KRAS; Medicine; Multiplicity of infection; Cetuximab; Cancer; Camptothecin; Cancer research; Immunology; Internal medicine; Pharmacology; Oncology; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196473,0.0004604588,0.0004123706,0.0002477704,0.0001353285,0.0002207499,0.0001803624,0.0002819795,0.002632925],"category_scores_gemma":[0.00008658473,0.0001144571,0.0003446033,0.0002393856,0.0001543509,0.0001435994,0.0001299916,0.0005800126,0.0005371527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310921,"about_ca_system_score_gemma":0.0002830429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00157204,"about_ca_topic_score_gemma":0.001709414,"domain_scores_codex":[0.9998475,0.00003129611,0.00001684329,0.00002331894,0.00004485304,0.00003619715],"domain_scores_gemma":[0.9999101,0.00002416215,0.00001526702,0.0000144787,0.0000137638,0.00002227597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005690492,0.0002192409,0.0002334107,0.0001010455,0.00001495173,0.0000920372,0.00002016245,0.0001816638,0.9959382,0.00008177952,0.0003571267,0.002191346],"study_design_scores_gemma":[0.00004425407,0.001545105,0.002823805,0.000006899577,0.00001569865,0.0002383889,0.00001745193,0.0005463454,0.9925435,0.00001267961,0.002201778,0.000004038055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910693,0.002486049,0.001200559,0.000133606,0.00009787888,0.00007839098,0.0008757485,0.00009328293,0.003965267],"genre_scores_gemma":[0.9913303,0.0009291744,0.002007923,0.00005806443,0.000017719,0.00006322008,0.001653809,0.00001818274,0.003921693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002632925,"threshold_uncertainty_score":0.008807957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04272875630085105,"score_gpt":0.4112074015439506,"score_spread":0.3684786452430996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}