{"id":"W2008250413","doi":"10.1021/ml500427r","title":"Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT<sub>2</sub> Receptor Ligands","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Kjell och Märta Beijers Stiftelse; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Stiftelsen för Strategisk Forskning","keywords":"Imidazole; Agonist; Substituent; Chemistry; Methylene; Stereochemistry; Biphenyl; Antagonist; Receptor; Derivative (finance); G protein-coupled receptor; Partial agonist; Combinatorial chemistry; Pharmacology; Biochemistry; Medicinal chemistry; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885593,0.0001805139,0.000194805,0.00002753916,0.0000681271,0.000009067653,0.000142887,0.0001472414,0.0001404589],"category_scores_gemma":[0.00006849613,0.000173852,0.00008047568,0.00007155859,0.0001024742,0.00001009252,0.00008121335,0.0001624562,0.000004777482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006570087,"about_ca_system_score_gemma":0.00002859242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002445374,"about_ca_topic_score_gemma":0.000008227355,"domain_scores_codex":[0.9989293,0.00003119521,0.000243096,0.0003449439,0.0002264206,0.0002250442],"domain_scores_gemma":[0.9994776,0.00002697989,0.0001365249,0.0002133003,0.00004798504,0.00009759959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002039006,0.00002032912,0.0007993062,0.00004831342,0.00002473836,0.000001019557,0.0000555726,0.00005026723,0.990124,0.000001484591,0.007836061,0.0008349658],"study_design_scores_gemma":[0.000848246,0.00006799756,0.0002991045,0.00005065424,0.00001460054,0.00001338652,0.0000551889,0.0001692934,0.9975771,0.000006327788,0.000727463,0.0001706114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970653,0.00006360314,0.001836117,0.0006061607,0.0002435439,0.00007255941,0.00002056475,0.000007592283,0.0000845429],"genre_scores_gemma":[0.9985236,0.000019655,0.00007991406,0.000477531,0.0003765747,0.00001111385,0.0003929433,0.00001640045,0.0001022973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007453084,"threshold_uncertainty_score":0.708948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004885806709513032,"score_gpt":0.1982484594449402,"score_spread":0.1933626527354272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}