{"id":"W2008263504","doi":"10.1634/stemcells.2008-0433","title":"Derivation and Characterization of Canine Embryonic Stem Cell Lines with In Vitro and In Vivo Differentiation Potential","year":2008,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Biology; Embryoid body; Germ layer; Embryonic stem cell; Homeobox protein NANOG; Endoderm; Cell biology; SOX2; Ectoderm; Stem cell; Cellular differentiation; KOSR; Induced pluripotent stem cell; Inner cell mass; Immunology; Blastocyst; Embryo; Embryogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008507752,0.0003051772,0.0004589626,0.0008364864,0.000366557,0.0006218739,0.0005460672,0.0004059556,0.00204891],"category_scores_gemma":[0.0007629168,0.0003043961,0.0003563713,0.0006809128,0.000337049,0.0003243301,0.0003124478,0.0007326877,0.001514383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439945,"about_ca_system_score_gemma":0.0005340422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303076,"about_ca_topic_score_gemma":0.002594268,"domain_scores_codex":[0.9992331,0.00007845269,0.0001640442,0.00009315083,0.0003460838,0.00008523076],"domain_scores_gemma":[0.9992294,0.0001318308,0.0001171956,0.0001527939,0.0002714838,0.00009723064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186978,0.0001318457,0.001912249,0.0002232828,0.00001519564,0.0003335643,0.0002189434,0.0004497158,0.9844511,0.001483303,0.0008475028,0.009814708],"study_design_scores_gemma":[0.00006966745,0.000790646,0.01219232,0.00007582695,0.0001162661,0.002600206,0.0001775218,0.002537874,0.8996521,0.0003158015,0.08143213,0.0000395641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8316917,0.007315271,0.1182343,0.0006721912,0.0003699194,0.003018525,0.01802393,0.000700023,0.01997424],"genre_scores_gemma":[0.7827774,0.008510762,0.1361038,0.0003519914,0.0001332633,0.002332594,0.04782179,0.0004047275,0.02156365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204891,"threshold_uncertainty_score":0.006854296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007328584412573971,"score_gpt":0.2003965163354764,"score_spread":0.1930679319229024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}