{"id":"W2008263504","doi":"10.1634/stemcells.2008-0433","title":"Derivation and Characterization of Canine Embryonic Stem Cell Lines with In Vitro and In Vivo Differentiation Potential","year":2008,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University of Toronto; Heart and Stroke Foundation of Canada","keywords":"Biology; Embryoid body; Germ layer; Embryonic stem cell; Homeobox protein NANOG; Endoderm; Cell biology; SOX2; Ectoderm; Stem cell; Cellular differentiation; KOSR; Induced pluripotent stem cell; Inner cell mass; Immunology; Blastocyst; Embryo; Embryogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000826295,0.0001060228,0.0001452248,0.0001076031,0.00003166851,0.000009744428,0.00005244911,0.00009028855,0.000002987777],"category_scores_gemma":[8.896567e-7,0.00009718096,0.00001337208,0.0001141772,0.00004849733,0.00001064281,0.00005465989,0.00005648419,4.656764e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001433086,"about_ca_system_score_gemma":0.00004097141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003707968,"about_ca_topic_score_gemma":0.00006407197,"domain_scores_codex":[0.9992173,0.00006583413,0.000190625,0.0002443073,0.0001285487,0.0001533285],"domain_scores_gemma":[0.9996895,0.000006570278,0.00009593523,0.0001178801,0.00005228444,0.00003782411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000254701,0.00005113237,0.009203818,0.0001053193,0.000005951312,0.000006302571,0.00009513997,0.00005718659,0.9896672,4.905738e-7,0.000003891709,0.0005488145],"study_design_scores_gemma":[0.00094789,0.0001100732,0.0619039,0.00002220713,0.000004542107,0.000009474063,0.00004402821,0.001238587,0.9355924,5.479997e-7,0.00003296188,0.00009345995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989552,0.0002294104,0.0004440229,0.00003167179,0.00002792797,0.0002536975,0.00002225169,0.00000327708,0.00003246339],"genre_scores_gemma":[0.9984009,0.0007130689,0.00004943112,0.000009886811,0.00002770642,0.0000110856,0.0000748126,0.00001376404,0.0006993898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05407492,"threshold_uncertainty_score":0.3962924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007328584412573971,"score_gpt":0.2003965163354764,"score_spread":0.1930679319229024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}