{"id":"W2008268931","doi":"10.1016/j.bmcl.2013.01.063","title":"Ester hydrolysis by a histidine-containing cavitein","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Chemistry; Hydrolysis; Histidine; Catalysis; Ester hydrolysis; Organic chemistry; Stereochemistry; Enzyme; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833608,0.0001917347,0.0001647896,0.00008625493,0.00009629147,0.0002195444,0.000205703,0.0002483049,0.0008127998],"category_scores_gemma":[0.0001886154,0.00006219427,0.0001321702,0.0001105437,0.0001306286,0.0002289479,0.0001567281,0.0002418378,0.0002900613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002747497,"about_ca_system_score_gemma":0.0001431609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004788766,"about_ca_topic_score_gemma":0.0003755641,"domain_scores_codex":[0.9999057,0.00001740869,0.000005490074,0.00002151972,0.0000162204,0.00003369386],"domain_scores_gemma":[0.9999284,0.00002200098,0.00001743348,0.000008427634,0.000007702974,0.00001603337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004344248,0.00003034674,0.0001898068,0.00001889306,0.000005342671,0.0001156528,0.00002086085,0.0002525134,0.99672,0.0001647669,0.00003784002,0.002009556],"study_design_scores_gemma":[0.000009964619,0.0001200379,0.0002993808,0.000001107268,0.000002599917,0.00007065775,0.000005839201,0.0006581609,0.9983041,0.00001828493,0.0005068841,0.000002895354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966671,0.000127476,0.002222254,0.00003394554,0.000009417189,0.000007677288,0.00005433568,0.00003066393,0.0008472137],"genre_scores_gemma":[0.9976986,0.00006840353,0.0007201781,0.000009101364,0.000002610346,0.000002593216,0.0001325778,0.00001028634,0.001355654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008127998,"threshold_uncertainty_score":0.002719104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003472218435889612,"score_gpt":0.1844596591523971,"score_spread":0.1809874407165075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}