{"id":"W2008296758","doi":"10.1016/j.molbiopara.2006.11.007","title":"Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani","year":2006,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies; National Institute for Health and Care Research","keywords":"IMP dehydrogenase; Biology; Biochemistry; Leishmania donovani; NAD+ kinase; Inosine; Enzyme; Molecular biology; Dehydrogenase; Nucleotide; Mycophenolic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684831,0.0003955592,0.0002790866,0.0003936867,0.0001295117,0.0004428911,0.000429105,0.0002647745,0.0006072811],"category_scores_gemma":[0.0004180653,0.0002369703,0.0002217407,0.0003696597,0.0002540869,0.0004499459,0.0001712785,0.00049078,0.0003970863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002656,"about_ca_system_score_gemma":0.0002152807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009517024,"about_ca_topic_score_gemma":0.0006203029,"domain_scores_codex":[0.9998342,0.00003314221,0.00001208146,0.00003557736,0.00004464793,0.00004035836],"domain_scores_gemma":[0.9997339,0.00007775767,0.00003657423,0.0000382608,0.0000759499,0.00003760582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004708774,0.0000565448,0.001217088,0.00007212388,0.000009035199,0.00006315046,0.00003873871,0.0001960855,0.9952565,0.0004555538,0.00004007879,0.002124231],"study_design_scores_gemma":[0.0000171978,0.0002889153,0.009796686,0.000006925372,0.00001776129,0.0003090164,0.00007225812,0.003119342,0.9840731,0.0001872071,0.002098239,0.00001339591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876205,0.002216685,0.006907275,0.0001280767,0.00004080676,0.0000386875,0.0008103824,0.00005665734,0.002180781],"genre_scores_gemma":[0.9937071,0.0005300319,0.001831574,0.00002246492,0.00001115441,0.00001950915,0.002070769,0.00001493794,0.001792346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009517024,"threshold_uncertainty_score":0.002904117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004571231094621861,"score_gpt":0.2453671231895013,"score_spread":0.2407958920948794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}