{"id":"W2008301786","doi":"10.1021/bi5014886","title":"Hydrophobic Blocks Facilitate Lipid Compatibility and Translocon Recognition of Transmembrane Protein Sequences","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Cancerfonden; European Research Council; Vetenskapsrådet","keywords":"Translocon; Transmembrane protein; Compatibility (geochemistry); Chemistry; Transmembrane domain; Biophysics; Cell biology; Biochemistry; Membrane protein; Computational biology; Membrane; Biology; Receptor; Engineering; Chemical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138464,0.0002572123,0.0001578376,0.000136824,0.0001390731,0.0003207374,0.00009533288,0.0001794994,0.0009343886],"category_scores_gemma":[0.0003059087,0.0001654521,0.0001640759,0.00008314351,0.0002190234,0.0002637953,0.0003237814,0.0002164035,0.0003287948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001331978,"about_ca_system_score_gemma":0.0001243111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001822992,"about_ca_topic_score_gemma":0.0003356945,"domain_scores_codex":[0.9998239,0.00005379353,0.00001333494,0.00002457489,0.00005034986,0.0000340886],"domain_scores_gemma":[0.999691,0.00009768292,0.00009007799,0.00002658341,0.00003138041,0.00006328489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004249561,0.00000632793,0.0001352389,0.000006684385,0.000001179625,0.0000151968,0.000007166294,0.00004997498,0.9993879,0.00005086393,0.00000179447,0.000295211],"study_design_scores_gemma":[0.00001054561,0.000288825,0.004411645,0.000003437151,0.000007733412,0.0001345063,0.0000175323,0.0008592648,0.9935645,0.00004940082,0.000649203,0.000003461123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981151,0.0000749413,0.001292704,0.00001417418,0.00000152244,0.00001076169,0.00002407866,0.00001044718,0.0004562949],"genre_scores_gemma":[0.9979315,0.00007542449,0.001458632,0.00001035836,0.000003075234,0.00000969015,0.00006968491,0.000006698845,0.0004349023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009343886,"threshold_uncertainty_score":0.003125846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119736236526394,"score_gpt":0.2497052081401741,"score_spread":0.2185078457749102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}