{"id":"W2008304259","doi":"10.1074/jbc.m413410200","title":"Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Canadian Institutes of Health Research","funders":"","keywords":"RNA; Virology; RNA-dependent RNA polymerase; RNA polymerase; Polymerase; Nucleoside; Biology; Genotype; Virus; Chemistry; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649298,0.000141285,0.000453606,0.0000542223,0.00005197494,0.000009084275,0.000141908,0.0001931942,0.0003029079],"category_scores_gemma":[0.000368456,0.00008783161,0.0001604138,0.0001337314,0.0003141205,0.00009123085,0.0001045929,0.0004335442,6.699994e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007454678,"about_ca_system_score_gemma":0.000151833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003075728,"about_ca_topic_score_gemma":0.00003086359,"domain_scores_codex":[0.9981843,0.00006054192,0.000922917,0.0001159611,0.0005318449,0.0001844872],"domain_scores_gemma":[0.9984613,0.000101361,0.0007622485,0.0001702745,0.0003348677,0.0001699622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002021591,0.0001283053,0.007126788,0.0001208299,0.00005981828,0.00001091655,0.00008865917,0.00001060952,0.9890488,0.00002485911,0.0004364561,0.002741768],"study_design_scores_gemma":[0.001264544,0.0003768037,0.01068844,0.000176482,0.00004426786,0.0001131607,0.00008231171,0.00004690625,0.9868302,0.0002192646,0.0000802343,0.00007734866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978364,0.0004100582,0.0001261417,0.0003647251,0.00003918528,0.000147911,0.0002413995,0.000004245633,0.0008299487],"genre_scores_gemma":[0.9985893,0.0005266073,0.0005793027,0.0000973982,0.000140633,0.000001831585,0.00001818662,0.000008943278,0.00003783115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003561655,"threshold_uncertainty_score":0.3581669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400915041713956,"score_gpt":0.2743761662205319,"score_spread":0.2603670158033923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}