{"id":"W2008325410","doi":"10.1038/nbt1107","title":"Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants","year":2005,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Polyunsaturated fatty acid; Docosahexaenoic acid; Eicosapentaenoic acid; Biochemistry; Arachidonic acid; Fatty acid; Metabolic engineering; Chemistry; Food science; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001642911,0.0002051896,0.0002698969,0.0002887268,0.00002076781,0.000006309315,0.000359317,0.001712179,0.000007189649],"category_scores_gemma":[0.0002946241,0.0001838491,0.00004975871,0.0003264651,0.00005089397,0.000005368458,0.0001665379,0.0004833339,0.000008996176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002030023,"about_ca_system_score_gemma":0.00005125036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001396957,"about_ca_topic_score_gemma":0.0001130591,"domain_scores_codex":[0.9988052,0.00002293746,0.0002596163,0.0004562612,0.0001145643,0.0003414299],"domain_scores_gemma":[0.9993037,0.00001332358,0.00006738014,0.0005147756,0.00004277883,0.00005806684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001397985,0.00007978729,0.0013616,0.00002054341,0.00003124573,0.000005546745,0.00002258456,0.00007130836,0.9798144,0.0001249774,0.0002589368,0.0180693],"study_design_scores_gemma":[0.0003292614,0.00009218512,0.01817371,0.00002946563,0.000007632275,0.0000139069,0.00001431682,0.0000192085,0.9387446,0.000002398393,0.04237855,0.0001947776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994737,0.002558795,0.0002612384,0.00176681,0.0003471497,0.0002169225,0.00003452829,0.00005395191,0.00002356894],"genre_scores_gemma":[0.9951131,0.0001624165,0.003930436,0.0002869841,0.0003350889,0.00001166126,0.00004547401,0.00002230657,0.00009254757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04211961,"threshold_uncertainty_score":0.9995838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0033007674887853,"score_gpt":0.2060370599067687,"score_spread":0.2027362924179834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}