{"id":"W2008355700","doi":"10.1089/hum.2010.126","title":"T-Cell Receptor Gene Therapy in Human Melanoma-Bearing Immune-Deficient Mice: Human but not Mouse T Cells Recapitulate Outcome of Clinical Studies","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Erasmus+; Institute of Genetics; Erasmus Medisch Centrum; European Commission","keywords":"Genetic enhancement; Immune system; Immunology; Melanoma; Biology; Receptor; Cancer research; Cell therapy; Gene; Cell; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003443243,0.0007445009,0.002446744,0.000733791,0.0003841833,0.00004226641,0.0008930182,0.0004200962,0.003595705],"category_scores_gemma":[0.00002871397,0.0006294231,0.0009140099,0.0004593593,0.000673407,0.0001195329,0.0002545903,0.00107783,0.0001254824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632051,"about_ca_system_score_gemma":0.0001139769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008045198,"about_ca_topic_score_gemma":0.00005804195,"domain_scores_codex":[0.9931434,0.0007835492,0.0029458,0.001147681,0.000921749,0.001057792],"domain_scores_gemma":[0.9965127,0.0002132715,0.0007809309,0.001823942,0.0003616082,0.0003075958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001550668,0.00239278,0.01265384,0.0001614343,0.0006476697,0.00006669606,0.006415384,0.000005913064,0.9671038,0.00007900611,0.00007170997,0.008851124],"study_design_scores_gemma":[0.01123331,0.004148913,0.0136283,0.0001276463,0.00005748423,0.00001343303,0.000681533,0.000005135101,0.9667569,0.0001075903,0.002624118,0.0006156155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561322,0.04014511,0.000005112299,0.00003185567,0.0003196694,0.001953131,0.00001793756,0.0001537138,0.001241321],"genre_scores_gemma":[0.9172092,0.07140375,0.0008278011,0.0002265991,0.000371811,0.0001411792,0.0000479404,0.0002505548,0.009521173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03892296,"threshold_uncertainty_score":0.9996157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2557074416545946,"score_gpt":0.4232898042773448,"score_spread":0.1675823626227501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}