{"id":"W2008355700","doi":"10.1089/hum.2010.126","title":"T-Cell Receptor Gene Therapy in Human Melanoma-Bearing Immune-Deficient Mice: Human but not Mouse T Cells Recapitulate Outcome of Clinical Studies","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Erasmus+; Institute of Genetics; Erasmus Medisch Centrum; European Commission","keywords":"Genetic enhancement; Immune system; Immunology; Melanoma; Biology; Receptor; Cancer research; Cell therapy; Gene; Cell; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005555503,0.0006244503,0.0006043187,0.000425155,0.000137992,0.0004382661,0.0002301665,0.0005984859,0.001155403],"category_scores_gemma":[0.0002276501,0.0001597146,0.0003538896,0.0002480806,0.0003068433,0.0003291367,0.0001486106,0.001064363,0.0005234061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673222,"about_ca_system_score_gemma":0.0003082966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003849361,"about_ca_topic_score_gemma":0.0003581485,"domain_scores_codex":[0.9996898,0.00007969301,0.00003842645,0.00006715363,0.00005988007,0.00006515833],"domain_scores_gemma":[0.9998677,0.00001831485,0.0000344207,0.00003875755,0.00001526765,0.00002551273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005320552,0.0003906902,0.0002827975,0.00005554043,0.00001293245,0.00007653229,0.00003213358,0.0002128291,0.9954032,0.0001336761,0.0001137183,0.002753902],"study_design_scores_gemma":[0.0002214857,0.007331252,0.003666182,0.00002153595,0.00009713232,0.001295192,0.00002982273,0.001333187,0.9795151,0.0001121731,0.006364896,0.00001206847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877396,0.002703103,0.006171132,0.0001341822,0.00006878016,0.0003578927,0.0006429958,0.0002155096,0.001966788],"genre_scores_gemma":[0.9911811,0.001674359,0.003328646,0.000120871,0.00002348507,0.0003335841,0.001021029,0.00006182625,0.002255029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155403,"threshold_uncertainty_score":0.003865242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2557074416545946,"score_gpt":0.4232898042773448,"score_spread":0.1675823626227501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}