{"id":"W2008368193","doi":"10.1016/j.joca.2008.03.009","title":"Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes","year":2008,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Intégré de Santé et de Services Sociaux des Laurentides; Centre Hospitalier de l’Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Prostaglandin E2; Nitric oxide; Histone deacetylase; Chemistry; Interleukin; Interleukin 1β; Dinoprostone; Pharmacology; Cell biology; Cancer research; Medicine; Histone; Immunology; Cytokine; Biology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305228,0.0003649497,0.0004224515,0.0002223606,0.0002176056,0.0003241394,0.000248582,0.000181637,0.001680727],"category_scores_gemma":[0.0002150333,0.0002029262,0.0003836742,0.000194669,0.0003085954,0.0001326314,0.0001739741,0.0005161448,0.0003441266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081973,"about_ca_system_score_gemma":0.0004315155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002228036,"about_ca_topic_score_gemma":0.003460681,"domain_scores_codex":[0.999836,0.00002296416,0.00002390825,0.00002370388,0.00002916083,0.00006420918],"domain_scores_gemma":[0.9998698,0.00002775706,0.00002740142,0.00002009577,0.00001682049,0.00003809694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004143281,0.0003367144,0.0005927696,0.00008965428,0.00003534448,0.0001425958,0.00006317274,0.00005577027,0.9893936,0.00004953697,0.0001945143,0.004903012],"study_design_scores_gemma":[0.001275294,0.007395901,0.02574784,0.00001827184,0.0001275977,0.0006953539,0.0002876921,0.000685407,0.9594618,0.00007838504,0.004211414,0.00001498668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940968,0.004329723,0.0004772869,0.0001045796,0.0001084415,0.00002701439,0.0001920643,0.00002479869,0.0006393155],"genre_scores_gemma":[0.9944099,0.002117207,0.0003824025,0.00007907925,0.00005154415,0.0000280176,0.0006281465,0.000009471631,0.002294203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002228036,"threshold_uncertainty_score":0.005622625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402208686689922,"score_gpt":0.2474548599179148,"score_spread":0.2334327730510156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}