{"id":"W2008368193","doi":"10.1016/j.joca.2008.03.009","title":"Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes","year":2008,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Intégré de Santé et de Services Sociaux des Laurentides; Centre Hospitalier de l’Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Prostaglandin E2; Nitric oxide; Histone deacetylase; Chemistry; Interleukin; Interleukin 1β; Dinoprostone; Pharmacology; Cell biology; Cancer research; Medicine; Histone; Immunology; Cytokine; Biology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001554941,0.0003130822,0.0005052098,0.000306623,0.0002673181,0.00004139199,0.00004592114,0.0001672431,0.00003725606],"category_scores_gemma":[0.00005465657,0.0003039195,0.00007585022,0.0002396557,0.0001703025,0.0002896963,0.00006990887,0.0002591749,0.0000108119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001010956,"about_ca_system_score_gemma":0.00004766276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005922022,"about_ca_topic_score_gemma":0.0004626475,"domain_scores_codex":[0.9982139,0.00006680406,0.0004192161,0.0006049416,0.0002641951,0.0004308822],"domain_scores_gemma":[0.9992866,0.00002167372,0.00009680732,0.0002758293,0.00006349424,0.0002555826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002261165,0.0001811024,0.0143804,0.00007971068,0.000003717421,0.0009937002,0.001003045,1.047938e-7,0.9688909,0.00005568214,0.0001895948,0.01399594],"study_design_scores_gemma":[0.008486462,0.002664923,0.007879863,0.0005181011,0.00006264216,0.002342306,0.0006131223,7.350822e-7,0.9759759,0.00007043809,0.001034357,0.0003511662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992593,0.005186862,2.579912e-7,0.0001659602,0.0001970135,0.001034004,0.00001470679,0.00009740163,0.0007108041],"genre_scores_gemma":[0.9968124,0.0005230038,0.00009227939,0.00008023725,0.0001820249,0.000160307,0.00007301401,0.00004618977,0.002030534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01364477,"threshold_uncertainty_score":0.9999413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402208686689922,"score_gpt":0.2474548599179148,"score_spread":0.2334327730510156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}